Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target? (Q38190986)

30 August 2017

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title

Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target? (English)

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30 August 2017

Maria Sole Chimenti

3

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Emma Guttman-Yassky

series ordinal

4

object named as

Emma Guttman-Yassky

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30 August 2017

5

James G Krueger

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30 August 2017

1

Andrea Chiricozzi

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30 August 2017

Rosita Saraceno

2

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PubMed ID

24568095

30 August 2017

language of work or name

English

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publication date

25 February 2014

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Expert Opinion on Therapeutic Targets

30 August 2017

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30 August 2017

18

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30 August 2017

5

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30 August 2017

513-525

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Targeting IL-23 in human diseases.

30 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Interleukin-23: as a drug target for autoimmune inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Expression and regulation of interleukin-23 subunits in human peripheral blood mononuclear cells and hematopoietic cell lines in response to various inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

AP-1 activated by toll-like receptors regulates expression of IL-23 p19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Reconciling id, ego, and superego within interleukin-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

A unique role for IL-23 in promoting cellular immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Development, cytokine profile and function of human interleukin 17-producing helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Distinct regulation of interleukin-17 in human T helper lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-23 drives pathogenic IL-17-producing CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

gammadelta T cells: an important source of IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The approach to psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The effects of cyclosporin A on T lymphocyte and dendritic cell sub-populations in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

T-lymphocyte-activating properties of epidermal antigen-presenting cells from normal and psoriatic skin: evidence that psoriatic epidermal antigen-presenting cells resemble cultured normal Langerhans cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Mouse models of psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Dermal injection of immunocytes induces psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Resident and "inflammatory" dendritic cells in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Circulating Th17, Th22, and Th1 cells are increased in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

The IL-17 cytokine family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Long-term safety experience of ustekinumab in patients with moderate-to-severe psoriasis (Part I of II): results from analyses of general safety parameters from pooled Phase 2 and 3 clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.889686

10.1517/14728222.2014.889686

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24568095