Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome (Q38195470)

30 August 2017

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title

Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome (English)

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30 August 2017

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Lee D Roberts

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Albert Koulman

object named as

Albert Koulman

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2

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Julian L Griffin

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3

object named as

Julian L Griffin

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30 August 2017

3 December 2013

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The Lancet: Diabetes & Endocrinology

30 August 2017

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30 August 2017

2

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30 August 2017

65-75

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30 August 2017

1

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Systematic functional analysis of the yeast genome

30 August 2017

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Systems biology: Metabonomics.

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Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

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Metabolite profiles during oral glucose challenge.

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High-throughput direct-infusion ion trap mass spectrometry: a new method for metabolomics

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High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

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7 January 2021

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse

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Biomarkers and surrogate markers: an FDA perspective

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Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

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Genetic susceptibility to type 2 diabetes and implications for therapy

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Diet, inflammation, and glycemic control in type 2 diabetes: an integrative review of the literature

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Environmental pollution and diabetes: a neglected association.

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Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders.

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Year in diabetes 2012: The diabetes tsunami

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A matter of fat: an introduction to lipidomic profiling methods

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Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

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¹H NMR-based metabonomics for investigating diabetes

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Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook

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Metabolomics and cardiovascular biomarker discovery

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7 January 2021

THE METABOLISM OF AMINO ACIDS IN DIABETES MELLITUS.

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Plasma Amino Acid Levels and Insulin Secretion in Obesity

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Stimulation of insulin secretion by amino acids

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7 January 2021

Secretion of insulin induced by amino acids and glucose in diabetes mellitus

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Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

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7 January 2021

An amino acid profile to predict diabetes?

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7 January 2021

Bidirectional modulation of insulin action by amino acids

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7 January 2021

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

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7 January 2021

Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

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Bile acid signaling after an oral glucose tolerance test

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7 January 2021

Metabolite profiles and the risk of developing diabetes

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A diabetes-predictive amino acid score and future cardiovascular disease

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Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

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Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women

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7 January 2021

Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

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7 January 2021

Metabolite profiling identifies pathways associated with metabolic risk in humans

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7 January 2021

Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes

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7 January 2021

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

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7 January 2021

Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients.

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A signaling role of glutamine in insulin secretion

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The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

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Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

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Novel biomarkers for pre-diabetes identified by metabolomics

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A sweet spot for the bariatric surgeon

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Medicine. Bypassing medicine to treat diabetes

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Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery

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Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss

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7 January 2021

Interplay between lipids and branched-chain amino acids in development of insulin resistance

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7 January 2021

Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

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7 January 2021

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7 January 2021

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

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Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

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7 January 2021

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

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7 January 2021

Amino acid regulation of TOR complex 1.

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7 January 2021

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

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Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

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Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach

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7 January 2021

A genome-wide perspective of genetic variation in human metabolism

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7 January 2021

A genome-wide association study of metabolic traits in human urine

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7 January 2021

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

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A genome-wide association study of the human metabolome in a community-based cohort

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Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological study

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A microfluidic device for the automated derivatization of free fatty acids to fatty acidmethylesters

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7 January 2021

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

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7 January 2021

Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Nor

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7 January 2021

Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid

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Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study

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7 January 2021

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

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7 January 2021

A dual sugar challenge test for lipogenic sensitivity to dietary fructose

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7 January 2021

Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver

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7 January 2021

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

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The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids.

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Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men.

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Plasma phospholipid fatty acids in the central Canadian arctic: biocultural explanations for ethnic differences

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Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

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7 January 2021

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

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7 January 2021

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.

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7 January 2021

Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention

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7 January 2021

Plasma fatty acids and desaturase activity are associated with circulating adiponectin in healthy adolescent girls.

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7 January 2021

Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents.

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Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids

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Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

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ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism

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7 January 2021

Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations.

1 reference

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7 January 2021

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

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Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin

1 reference

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7 January 2021

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

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7 January 2021

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Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24622670