Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis (Q38195943)

30 August 2017

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title

Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis (English)

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30 August 2017

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4

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30 August 2017

T Hendrikx

1

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PubMed ID

24629059

30 August 2017

S M A Walenbergh

series ordinal

2

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PubMed ID

24629059

30 August 2017

M H Hofker

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3

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30 August 2017

16 March 2014

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30 August 2017

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30 August 2017

15

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30 August 2017

5

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30 August 2017

424-433

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The Cholesterol Derivative 27-Hydroxycholesterol Reduces Steatohepatitis in Mice

30 August 2017

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Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

21 January 2018

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Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester

21 January 2018

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Macrophages, inflammation, and insulin resistance

21 January 2018

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Role and function of macrophages in the metabolic syndrome

21 January 2018

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Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

21 January 2018

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21 January 2018

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

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Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells

21 January 2018

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Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

21 January 2018

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Oxidized LDL and the metabolic syndrome

21 January 2018

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The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort

21 January 2018

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Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease.

21 January 2018

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Uptake of oxidized LDL by macrophages differs from that of acetyl LDL and leads to expansion of an acidic endolysosomal compartment

21 January 2018

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Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells

21 January 2018

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Lysosomal acid lipase deficiency: correction of lipid storage by adenovirus-mediated gene transfer in mice

21 January 2018

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Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation

21 January 2018

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Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice

21 January 2018

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Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins

21 January 2018

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Macrophage uptake of cholesterol-containing particles derived from LDL and isolated from atherosclerotic lesions

21 January 2018

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Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta

21 January 2018

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Autophagy in human health and disease

21 January 2018

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A block of autophagy in lysosomal storage disorders

21 January 2018

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Monitoring autophagy in lysosomal storage disorders

21 January 2018

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Autophagy regulates lipid metabolism

21 January 2018

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Altered lipid content inhibits autophagic vesicular fusion

21 January 2018

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Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

21 January 2018

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Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes

21 January 2018

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Macrophage autophagy plays a protective role in advanced atherosclerosis

21 January 2018

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Autophagy links inflammasomes to atherosclerotic progression.

21 January 2018

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Autophagy: Emerging roles in lipid homeostasis and metabolic control

21 January 2018

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Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

21 January 2018

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Critical functions of priming and lysosomal damage for NLRP3 activation

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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The inflammasomes: mechanisms of activation and function

21 January 2018

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A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

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Cholesterol crystals as an etiological factor in non-resolving chronic inflammation: an experimental study in guinea pigs

21 January 2018

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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

21 January 2018

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Caspase-1 deficiency decreases atherosclerosis in apolipoprotein E-null mice.

21 January 2018

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Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

21 January 2018

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NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis

21 January 2018

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Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

21 January 2018

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Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis

21 January 2018

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Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

21 January 2018

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Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice

21 January 2018

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Cathepsin L activity controls adipogenesis and glucose tolerance

21 January 2018

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Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells

21 January 2018

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The lysosome: from waste bag to potential therapeutic target

21 January 2018

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Cathepsin-regulated apoptosis

21 January 2018

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Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis

21 January 2018

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Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

21 January 2018

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Trafficking of lysosomal enzymes in normal and disease states

21 January 2018

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Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge

21 January 2018

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Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

21 January 2018

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Cathepsin cysteine proteases in cardiovascular disease.

21 January 2018

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Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

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Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation

21 January 2018

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Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice

21 January 2018

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Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions

21 January 2018

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Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

21 January 2018

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The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

21 January 2018

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Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

21 January 2018

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NPC1/NPC2 function as a tag team duo to mobilize cholesterol

21 January 2018

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Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

21 January 2018

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Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

21 January 2018

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Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream.

21 January 2018

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Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

21 January 2018

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Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain

21 January 2018

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NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

21 January 2018

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Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells

21 January 2018

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Metabolism of cholesteryl ester lipid droplets in a J774 macrophage foam cell model

21 January 2018

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Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

21 January 2018

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Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects

21 January 2018

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Early atherogenesis in White Carneau pigeons: effect of a short-term regression diet

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins.

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Reduction of Atherosclerotic Plaques by Lysosomal Acid Lipase Supplementation

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Intracellular cholesterol transport

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Enhanced macrophage uptake of low density lipoprotein after self-aggregation

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Lysosomal storage diseases as disorders of autophagy

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Regulation of lipoprotein lipase secretion in murine macrophages during foam cell formation in vitro. Effect of triglyceride-rich lipoproteins

1 reference

28 October 2023

https://opencitations.net/index/coci/api/v1/references/10.1111/OBR.12159

Identifiers

DOI

10.1111/OBR.12159

1 reference

30 August 2017

1 reference

PubMed ID

24629059