Developments in preclinical cancer imaging: innovating the discovery of therapeutics. (Q38205100)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24739578%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Developments in preclinical cancer imaging: innovating the discovery of therapeutics (English)

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14 March 2020

1

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14 March 2020

Neil O Carragher

series ordinal

2

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14 March 2020

author name string

Paul Timpson

series ordinal

3

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14 March 2020

language of work or name

English

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publication date

17 April 2014

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14 March 2020

published in

Nature Reviews Cancer

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14 March 2020

volume

14

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14 March 2020

issue

5

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14 March 2020

page(s)

314-328

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The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines

14 March 2020

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Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

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How were new medicines discovered?

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Quantitative morphological signatures define local signaling networks regulating cell morphology.

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Validation of an algorithm to quantify changes in actin cytoskeletal organization

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Highly multiplexed phenotypic imaging for cell proliferation studies

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Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor

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A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

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Integrating high-content screening and ligand-target prediction to identify mechanism of action

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Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

31 March 2020

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Drug screening for autophagy inhibitors based on the dissociation of Beclin1-Bcl2 complex using BiFC technique and mechanism of eugenol on anti-influenza A virus activity

31 March 2020

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Establishment of a new detection system for the dimerization of IRE1α by BiFC assay

31 March 2020

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A near-infrared BiFC reporter for in vivo imaging of protein-protein interactions

31 March 2020

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Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.

31 March 2020

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Akt SUMOylation regulates cell proliferation and tumorigenesis

31 March 2020

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Analysis of protein and lipid dynamics using confocal fluorescence recovery after photobleaching (FRAP).

31 March 2020

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Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane

31 March 2020

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Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

31 March 2020

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Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

31 March 2020

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Deconstructing the cadherin-catenin-actin complex

31 March 2020

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Endocytosis is required for E-cadherin redistribution at mature adherens junctions

31 March 2020

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A two-tiered mechanism for stabilization and immobilization of E-cadherin.

31 March 2020

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Revisiting point FRAP to quantitatively characterize anomalous diffusion in live cells.

31 March 2020

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Solute diffusion is hindered in the mitochondrial matrix

31 March 2020

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Aurora B regulates MCAK at the mitotic centromere

31 March 2020

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Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores

31 March 2020

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The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules

31 March 2020

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In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics

31 March 2020

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Evidence for a common mode of transcription factor interaction with chromatin as revealed by improved quantitative fluorescence recovery after photobleaching.

31 March 2020

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A benchmark for chromatin binding measurements in live cells.

31 March 2020

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Dynamic binding of histone H1 to chromatin in living cells

31 March 2020

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A quantitative approach to analyze binding diffusion kinetics by confocal FRAP.

31 March 2020

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FRET and FRAP imaging: approaches to characterise tau and stathmin interactions with microtubules in cells

31 March 2020

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Dual role for microtubules in regulating cortical contractility during cytokinesis

31 March 2020

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Imaging protein complex formation in the autophagy pathway: analysis of the interaction of LC3 and Atg4B(C74A) in live cells using Förster resonance energy transfer and fluorescence recovery after photobleaching

31 March 2020

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Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling.

31 March 2020

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Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

31 March 2020

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DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

31 March 2020

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Dual imaging and photoactivated nanoprobe for controlled cell tracking.

31 March 2020

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Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

31 March 2020

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Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish

31 March 2020

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Optimization of cell morphology measurement via single-molecule tracking PALM.

31 March 2020

1 reference

A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution

31 March 2020

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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

31 March 2020

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Rab25 regulates invasion and metastasis in head and neck cancer.

31 March 2020

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Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis

31 March 2020

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Intravital imaging of metastatic behavior through a mammary imaging window.

31 March 2020

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N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

31 March 2020

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Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA

31 March 2020

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Imaging biochemistry inside cells

31 March 2020

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How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology

31 March 2020

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Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer

31 March 2020

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Visualizing the mechanical activation of Src.

31 March 2020

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In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

31 March 2020

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Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging

31 March 2020

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Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells

31 March 2020

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Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

31 March 2020

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Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells

31 March 2020

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Activity of Rho-family GTPases during cell division as visualized with FRET-based probes

31 March 2020

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Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

31 March 2020

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Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis

31 March 2020

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Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

31 March 2020

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Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors

31 March 2020

1 reference

A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine

31 March 2020

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Imaging calpain protease activity by multiphoton FRET in living mice

31 March 2020

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Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

31 March 2020

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Highlighted Ca²⁺ imaging with a genetically encoded 'caged' indicator

31 March 2020

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Monitoring dynamic protein interactions with photoquenching FRET.

31 March 2020

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Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET.

31 March 2020

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Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions

31 March 2020

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High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis.

31 March 2020

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In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays

31 March 2020

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FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ

31 March 2020

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Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.

31 March 2020

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High-throughput quantification of posttranslational modifications in situ by CA-FLIM.

31 March 2020

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FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

31 March 2020

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Advances in imaging cell-matrix adhesions

31 March 2020

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31 March 2020

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FRET or no FRET: a quantitative comparison

31 March 2020

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Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation.

31 March 2020

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In vivo imaging of immune cell trafficking in cancer

31 March 2020

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Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice.

31 March 2020

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Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse

31 March 2020

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Intravital imaging of stromal cell dynamics in tumors

31 March 2020

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Tumors as organs: complex tissues that interface with the entire organism

31 March 2020

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Multiplexed FRET to image multiple signaling events in live cells

31 March 2020

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Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells.

31 March 2020

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Probing rotation dynamics of biomolecules using polarization based fluorescence microscopy

31 March 2020

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Nuclease resistance of telomere-like oligonucleotides monitored in live cells by fluorescence anisotropy imaging

31 March 2020

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Nanoscale organization of multiple GPI-anchored proteins in living cell membranes.

31 March 2020

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A multi-functional imaging approach to high-content protein interaction screening

31 March 2020

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Red-shifted fluorescent proteins monitor enzymatic activity in live HT-1080 cells with fluorescence lifetime imaging microscopy (FLIM).

31 March 2020

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Phase differential enhancement of FLIM to distinguish FRET components of a biosensor for monitoring molecular activity of Membrane Type 1 Matrix Metalloproteinase in live cells

31 March 2020

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Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer

31 March 2020

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An orange fluorescent protein with a large Stokes shift for single-excitation multicolor FCCS and FRET imaging

31 March 2020

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Fluorescence lifetime imaging microscopy of chemotherapy-induced apoptosis resistance in a syngenic mouse tumor model.

31 March 2020

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Time-lapse observation of cellular function with fluorescent probe reveals novel CTL-target cell interactions

31 March 2020

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Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.

31 March 2020

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Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

31 March 2020

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Development of an optimized backbone of FRET biosensors for kinases and GTPases

31 March 2020

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Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter

31 March 2020

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Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells

31 March 2020

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Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation

31 March 2020

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Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

31 March 2020

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Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

31 March 2020

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A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo

31 March 2020

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Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

31 March 2020

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GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1.

31 March 2020

1 reference

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

31 March 2020

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In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors

31 March 2020

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Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors

31 March 2020

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Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

31 March 2020

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In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique

31 March 2020

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Real-time determination of intracellular oxygen in bacteria using a genetically encoded FRET-based biosensor

31 March 2020

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A genetically encoded ratiometric sensor to measure extracellular pH in microdomains bounded by basolateral membranes of epithelial cells

31 March 2020

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Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains

31 March 2020

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Reporter proteins for in vivo fluorescence without oxygen

31 March 2020

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Flavin mononucleotide-based fluorescent reporter proteins outperform green fluorescent protein-like proteins as quantitative in vivo real-time reporters

31 March 2020

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Simultaneous Recording of Multiple Cellular Events by FRET

31 March 2020

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Imaging activation of two Ras isoforms simultaneously in a single cell

31 March 2020

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Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors

31 March 2020

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Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins.

31 March 2020

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Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo

31 March 2020

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Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice

31 March 2020

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Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse

31 March 2020

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A mouse model for monitoring calpain activity under physiological and pathological conditions.

31 March 2020

1 reference

Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β 1 -Adrenergic but Locally Confined β 2 -Adrenergic Receptor–Mediated Signaling

31 March 2020

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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

31 March 2020

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Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

31 March 2020

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Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression

31 March 2020

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The multiple uses of fluorescent proteins to visualize cancer in vivo

31 March 2020

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Fluorescent proteins for FRET microscopy: monitoring protein interactions in living cells

31 March 2020

1 reference

Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells

31 March 2020

1 reference

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

31 March 2020

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Tumour-cell invasion and migration: diversity and escape mechanisms

31 March 2020

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New dimensions in cell migration

31 March 2020

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Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

31 March 2020

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Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions.

31 March 2020

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Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape

31 March 2020

1 reference

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

31 March 2020

1 reference

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

31 March 2020

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A novel organotypic model mimics the tumor microenvironment

31 March 2020

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

31 March 2020

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Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment

31 March 2020

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Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone

31 March 2020

1 reference

A Non-Mulberry Silk Fibroin Protein Based 3D In Vitro Tumor Model for Evaluation of Anticancer Drug Activity

31 March 2020

1 reference

Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells

31 March 2020

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Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells

31 March 2020

1 reference

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

31 March 2020

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

31 March 2020

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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

31 March 2020

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

31 March 2020

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

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Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

31 March 2020

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Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs

31 March 2020

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Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

31 March 2020

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Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions

31 March 2020

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Host epithelial geometry regulates breast cancer cell invasiveness

31 March 2020

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Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion

31 March 2020

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

31 March 2020

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

31 March 2020

1 reference

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

31 March 2020

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Targeting tumor architecture to favor drug penetration: a new weapon to combat chemoresistance in pancreatic cancer?

31 March 2020

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Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy

31 March 2020

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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

31 March 2020

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Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy.

31 March 2020

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Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity.

31 March 2020

1 reference

In vivo molecular target assessment of matrix metalloproteinase inhibition

31 March 2020

1 reference

Whole-animal cellular and molecular imaging to accelerate drug development

31 March 2020

1 reference

Fluorescence molecular imaging of small animal tumor models.

31 March 2020

1 reference

Whole-body imaging with fluorescent proteins

31 March 2020

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Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels

31 March 2020

1 reference

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system

31 March 2020

1 reference

Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model

31 March 2020

1 reference

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

31 March 2020

1 reference

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

31 March 2020

1 reference

Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis.

31 March 2020

1 reference

Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors

31 March 2020

1 reference

Intravital imaging of cancer stem cell plasticity in mammary tumors

31 March 2020

1 reference

Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy

31 March 2020

1 reference

A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation

31 March 2020

1 reference

Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level

31 March 2020

1 reference

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

31 March 2020

1 reference

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

31 March 2020

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β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

31 March 2020

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p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

31 March 2020

1 reference

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

31 March 2020

1 reference

Paneth cells in intestinal homeostasis and tissue injury

31 March 2020

1 reference

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

31 March 2020

1 reference

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

31 March 2020

1 reference

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

31 March 2020

1 reference

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

31 March 2020

1 reference

Interstitial guidance of cancer invasion

31 March 2020

1 reference

Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion

31 March 2020

1 reference

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

31 March 2020

1 reference

Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force

31 March 2020

1 reference

Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo

31 March 2020

1 reference

Automated analysis of clonal cancer cells by intravital imaging

31 March 2020

1 reference

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

31 March 2020

1 reference

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors

31 March 2020

1 reference

Macrophages regulate the angiogenic switch in a mouse model of breast cancer

31 March 2020

1 reference

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

31 March 2020

1 reference

Role of pancreatic stellate cells in pancreatic cancer metastasis.

31 March 2020

1 reference

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

31 March 2020

1 reference

Real-time imaging reveals the single steps of brain metastasis formation

31 March 2020

1 reference

Stretching the timescale of intravital imaging in tumors

31 March 2020

1 reference

Surgical implantation of an abdominal imaging window for intravital microscopy

31 March 2020

1 reference

Single cell analysis of drug distribution by intravital imaging

31 March 2020

1 reference

A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport.

31 March 2020

1 reference

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.

31 March 2020

1 reference

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models

31 March 2020

1 reference

Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts

31 March 2020

1 reference

Tumor stroma as targets for cancer therapy

31 March 2020

1 reference

Functional immunoimaging: the revolution continues.

31 March 2020

1 reference

Molecular mechanisms and clinical applications of angiogenesis

31 March 2020

1 reference

Cancer immunotherapy comes of age

31 March 2020

1 reference

Targeted inhibition of VEGF receptor 2: an update on ramucirumab

31 March 2020

1 reference

Hedgehog signaling: from the cuirass to the heart of pancreatic cancer.

31 March 2020

1 reference

Color-coded fluorescence imaging of tumor-host interactions

31 March 2020

1 reference

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

31 March 2020

1 reference

GFP-expressing vascularization of Gelfoam as a rapid in vivo assay of angiogenesis stimulators and inhibitors

31 March 2020

1 reference

In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy

31 March 2020

1 reference

Cell lineage reconstruction of early zebrafish embryos using label-free nonlinear microscopy.

31 March 2020

1 reference

Intravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics.

31 March 2020

1 reference

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

31 March 2020

1 reference

Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer

31 March 2020

1 reference

Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment

31 March 2020

1 reference

Wide-field fluorescence lifetime imaging of cancer

31 March 2020

1 reference

Acidity generated by the tumor microenvironment drives local invasion

31 March 2020

1 reference

In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

31 March 2020

1 reference

Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

31 March 2020

1 reference

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

31 March 2020

1 reference

Imaging local neuronal activity by monitoring PO₂ transients in capillaries

31 March 2020

1 reference

A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications

31 March 2020

1 reference

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

31 March 2020

1 reference

Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

31 March 2020

1 reference

Multiplex profiling of cellular invasion in 3D cell culture models

31 March 2020

1 reference

Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens.

31 March 2020

1 reference

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

31 March 2020

1 reference

An Automated High-Content Assay for Tumor Cell Migration through 3-Dimensional Matrices

31 March 2020

1 reference

A programmable microfluidic cell array for combinatorial drug screening

31 March 2020

1 reference

Novel multiwavelength microscopic scanner for mouse imaging

31 March 2020

1 reference

In vivo imaging of green fluorescent protein-expressing cells in transgenic animals using fibred confocal fluorescence microscopy

31 March 2020

1 reference

A fluorescence lifetime imaging scanning confocal endomicroscope

31 March 2020

1 reference

Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy

31 March 2020

1 reference

An unmet medical need: advances in endoscopic imaging of colorectal neoplasia.

31 March 2020

1 reference

Use of multiphoton tomography and fluorescence lifetime imaging to investigate skin pigmentation in vivo.

31 March 2020

1 reference

The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo.

31 March 2020

1 reference

Changes in the redox state and endogenous fluorescence of in vivo human skin due to intrinsic and photo-aging, measured by multiphoton tomography with fluorescence lifetime imaging.

31 March 2020

1 reference

Imaging and quantifying the dynamics of tumor-associated proteolysis

31 March 2020

1 reference

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

31 March 2020

1 reference

Contribution of CXCL12 secretion to invasion of breast cancer cells.

31 March 2020

1 reference

Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis

31 March 2020

1 reference

Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging

31 March 2020

1 reference

An improved cerulean fluorescent protein with enhanced brightness and reduced reversible photoswitching

31 March 2020

1 reference

Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

31 March 2020

1 reference

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%.

31 March 2020

1 reference

Sensitive detection of p65 homodimers using red-shifted and fluorescent protein-based FRET couples

31 March 2020

1 reference

Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: basis of biosensor construction, live imaging, and image processing

31 March 2020

1 reference

FRET-based in vivo Ca2+ imaging by a new calmodulin-GFP fusion molecule

31 March 2020

1 reference

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

31 March 2020

1 reference

Dynamic and quantitative Ca2+ measurements using improved cameleons

31 March 2020

1 reference

Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications

31 March 2020

1 reference

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

31 March 2020

1 reference

Elimination of environmental sensitivity in a cameleon FRET-based calcium sensor via replacement of the acceptor with Venus.

31 March 2020

1 reference

Enhanced sensitivity of FRET-based protease sensors by redesign of the GFP dimerization interface

31 March 2020

1 reference

An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins

31 March 2020

1 reference

Evolutionary optimization of fluorescent proteins for intracellular FRET

31 March 2020

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Improving FRET dynamic range with bright green and red fluorescent proteins

31 March 2020

1 reference

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space

31 March 2020

1 reference

Antibody Detection by Using a FRET‐Based Protein Conformational Switch

31 March 2020

1 reference

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

31 March 2020

1 reference

Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects

31 March 2020

1 reference

Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation

31 March 2020

1 reference

A high-throughput FRET-based assay for determination of Atg4 activity

31 March 2020

1 reference

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

31 March 2020

1 reference

A genetically encoded fluorescent sensor of ERK activity

31 March 2020

1 reference

A Novel FRET-Based Biosensor for the Measurement of BCR-ABL Activity and Its Response to Drugs in Living Cells

31 March 2020

1 reference

A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse

31 March 2020

1 reference

Dendra2 photoswitching through the Mammary Imaging Window.

31 March 2020

1 reference

12 December 2020

GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice.

1 reference

12 December 2020

Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging

1 reference

12 December 2020

Optimizing imaging of three-dimensional multicellular tumor spheroids with fluorescent reporter proteins using confocal microscopy

1 reference

12 December 2020

Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context

1 reference

12 December 2020