P-Rex1 is required for efficient melanoblast migration and melanoma metastasis (Q34235334)

31 July 2017

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis (English)

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31 July 2017

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Patrizia Cammareri

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William J Faller

William J Faller

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Heidi Welch

Heidi C Welch

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Jennifer P. Morton

Jennifer P Morton

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Jim C Norman

Jim C Norman

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Ian J. Jackson

Ian J Jackson

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William M Gallagher

William M Gallagher

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Owen J Sansom

Owen J Sansom

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Laura Machesky

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Laura M Machesky

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31 July 2017

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Channing Der

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Richard L Mort

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Florian Rambow

Florian Rambow

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Paul Timpson

Paul Timpson

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Lionel Larue

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Lionel Larue

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31 July 2017

Colin R Lindsay

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31 July 2017

Samuel Lawn

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31 July 2017

Andrew D Campbell

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Ang Li

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Rachel A Ridgway

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Brendan Doyle

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Shauna Hegarty

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Mairin Rafferty

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Ian G Murphy

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Enda W McDermott

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Kieran Sheahan

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Katherine Pedone

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Alexander J Finn

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Pamela A Groben

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Nancy E Thomas

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Honglin Hao

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Craig Carson

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Leon Van Kempen

28

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Friedrich Beermann

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Brad W Ozanne

33

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31 July 2017

22 November 2011

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31 July 2017

Nature Communications

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2

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555

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describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3400057/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms1560

0 references

cites work

Embryonic signaling in melanoma: potential for diagnosis and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Integrative genome comparison of primary and metastatic melanomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Melanocytes in development and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Understanding melanoma signaling networks as the basis for molecular targeted therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Melanoma biology and new targeted therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Malignant melanoma: genetics and therapeutics in the genomic era.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Chemotherapy and targeted therapy combinations in advanced melanoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Genetically engineered models have advantages over xenografts for preclinical studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Contributions of human tumor xenografts to anticancer drug development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

P-Rex1 regulates neutrophil function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Tumour regulation of fibroblast hyaluronan expression: a mechanism to facilitate tumour growth and invasion.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

The Ras superfamily at a glance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Mutations of the BRAF gene in human cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Rac1 is required for cell proliferation and G2/M progression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Fos-transformation activates genes associated with invasion.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Melanoma--an unlikely poster child for personalized cancer therapy.

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

Ex vivo live imaging of melanoblast migration in embryonic mouse skin

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400057

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

28 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

Translating cancer research into targeted therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS1560

Loss of PTEN promotes tumor development in malignant melanoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22109529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS1560

1 reference

Dimensions Publication ID

31 July 2017

0 references

0 references

1 reference

31 July 2017

1 reference