NFAT, immunity and cancer: a transcription factor comes of age. (Q37781277)

23 August 2017

NFAT, immunity and cancer: a transcription factor comes of age. (English)

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23 August 2017

2

Anjana Rao

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23 August 2017

Martin R Müller

1

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23 August 2017

20 August 2010

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Nature Reviews Immunology

23 August 2017

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23 August 2017

10

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23 August 2017

645-656

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23 August 2017

9

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Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

23 August 2017

1 reference

Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells

21 January 2018

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Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.

21 January 2018

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HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT.

21 January 2018

1 reference

21 January 2018

B-1 B cell development

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The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.

21 January 2018

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Identification of a putative regulator of early T cell activation genes

21 January 2018

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

31 March 2020

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Nuclear factor of activated T cells contains Fos and Jun.

31 March 2020

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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

31 March 2020

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Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

31 March 2020

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NF-AT components define a family of transcription factors targeted in T-cell activation

31 March 2020

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Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

31 March 2020

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

31 March 2020

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Transcriptional regulation by calcium, calcineurin, and NFAT

31 March 2020

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NFAT proteins: key regulators of T-cell development and function

31 March 2020

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CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

31 March 2020

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Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT

31 March 2020

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Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes

31 March 2020

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Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

31 March 2020

1 reference

Calcineurin/NFAT signaling in osteoblasts regulates bone mass

31 March 2020

1 reference

Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

31 March 2020

1 reference

NFATc1 balances quiescence and proliferation of skin stem cells

31 March 2020

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Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.

31 March 2020

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NFAT proteins: emerging roles in cancer progression

31 March 2020

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SnapShot: Ca2+-calcineurin-NFAT signaling

31 March 2020

1 reference

Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity

31 March 2020

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NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun

31 March 2020

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Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression

31 March 2020

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Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress

31 March 2020

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Molecular basis of calcium signaling in lymphocytes: STIM and ORAI

31 March 2020

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Calcium signalling in lymphocyte activation and disease

31 March 2020

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

31 March 2020

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Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development

31 March 2020

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

31 March 2020

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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

31 March 2020

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Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

31 March 2020

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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.

31 March 2020

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Regulation of the murine Nfatc1 gene by NFATc2.

31 March 2020

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Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis

31 March 2020

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NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

31 March 2020

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A strategy for probing the function of noncoding RNAs finds a repressor of NFAT

31 March 2020

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Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.

31 March 2020

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Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

31 March 2020

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Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.

31 March 2020

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Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.

31 March 2020

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Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase

31 March 2020

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Regulation of transcription factor NFAT by ADP-ribosylation

31 March 2020

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Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.

31 March 2020

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Requirement for RORgamma in thymocyte survival and lymphoid organ development

31 March 2020

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Identification of common transcriptional regulatory elements in interleukin-17 target genes

31 March 2020

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Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase

31 March 2020

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

31 March 2020

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The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

31 March 2020

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A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.

31 March 2020

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Regulation of T-cell tolerance by calcium/NFAT signaling

31 March 2020

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Transcriptional mechanisms underlying lymphocyte tolerance.

31 March 2020

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

31 March 2020

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Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells

31 March 2020

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Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy

31 March 2020

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The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.

31 March 2020

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Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

31 March 2020

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Control of regulatory T cell lineage commitment and maintenance

31 March 2020

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

31 March 2020

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

31 March 2020

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Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

31 March 2020

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NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

31 March 2020

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FOXP3 controls regulatory T cell function through cooperation with NFAT

31 March 2020

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Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT

31 March 2020

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Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells.

31 March 2020

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Requirement for IL-13 independently of IL-4 in experimental asthma

31 March 2020

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Role of NFAT proteins in IL13 gene transcription in mast cells.

31 March 2020

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NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

31 March 2020

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Normal B-1a cell development requires B cell-intrinsic NFATc1 activity

31 March 2020

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The calcineurin phosphatase complex modulates immunogenic B cell responses

31 March 2020

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MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signaling pathways in B cells

31 March 2020

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31 March 2020

The biology of NKT cells

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The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells

31 March 2020

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Contribution of platelet-derived CD40 ligand to inflammation, thrombosis and neoangiogenesis.

31 March 2020

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Selective role of calcineurin in haematopoiesis and lymphopoiesis

31 March 2020

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Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34+ cells: regulation of Fas ligand gene expression in megakaryocytes

31 March 2020

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NFATc2-mediated repression of cyclin-dependent kinase 4 expression

31 March 2020

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The NFAT1 transcription factor is a repressor of cyclin A2 gene expression.

31 March 2020

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

31 March 2020

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NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor

31 March 2020

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A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts

31 March 2020

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The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

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The role of NFAT transcription factors in integrin-mediated carcinoma invasion

31 March 2020

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Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells

31 March 2020

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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

31 March 2020

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NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.

31 March 2020

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Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo

31 March 2020

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Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

31 March 2020

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VEGF-A and the induction of pathological angiogenesis

31 March 2020

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Discovery of vascular permeability factor (VPF).

31 March 2020

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Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

31 March 2020

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Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2

31 March 2020

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

31 March 2020

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Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway

31 March 2020

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NFATc1 regulates lymphatic endothelial development

31 March 2020

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FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

31 March 2020

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The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas

31 March 2020

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Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling

31 March 2020

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A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus

31 March 2020

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Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival

31 March 2020

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Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas

31 March 2020

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Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

31 March 2020

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Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

31 March 2020

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Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

31 March 2020

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NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells

31 March 2020

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TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.

31 March 2020

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NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma.

31 March 2020

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Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway

31 March 2020

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Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.

31 March 2020

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Linking calcineurin activity to leukemogenesis

31 March 2020

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A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

31 March 2020

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Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

31 March 2020

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Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20725108

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interaction of calcineurin with substrates and targeting proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20725108

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2818

1 reference

23 August 2017

1 reference

PubMed ID

20725108