Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease (Q38223953)

31 August 2017

title

Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease (English)

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31 August 2017

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2

Raja K Sivamani

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31 August 2017

Michael S Leo

1

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31 August 2017

publication date

28 June 2014

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Archives of Dermatological Research

31 August 2017

published in

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31 August 2017

volume

306

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31 August 2017

issue

10

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31 August 2017

page(s)

861-871

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Curcumin disrupts the Mammalian target of rapamycin-raptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTOR Inhibitors in Tuberous Sclerosis Complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTOR complex 2 in adipose tissue negatively controls whole-body growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

1α,25-Dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

The role of B-RAF in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTOR is activated in the majority of malignant melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Angiosarcoma: clinical and molecular insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

An emerging role of mTOR in lipid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

A comprehensive immunohistochemical approach of AKT/mTOR pathway and p-STAT3 in mycosis fungoides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Sgk kinases and their role in epithelial transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Activation of PI3K signaling in Merkel cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

The integral role of mTOR in lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Accelerated wound healing by mTOR activation in genetically defined mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Green tea extract and (-)-epigallocatechin-3-gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/AkT signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Activation of mTORC2 by association with the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00403-014-1480-8

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.1007/S00403-014-1480-8

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Dimensions Publication ID

31 August 2017

1037297144

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1 reference