Klotho: a novel biomarker for cancer (Q38236358)

31 August 2017

title

Klotho: a novel biomarker for cancer (English)

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31 August 2017

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Xiangxiang Zhou

1

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31 August 2017

Xin Wang

series ordinal

2

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31 August 2017

publication date

3 August 2014

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Journal of Cancer Research and Clinical Oncology

31 August 2017

published in

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31 August 2017

volume

141

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31 August 2017

issue

6

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31 August 2017

page(s)

961-969

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Small-molecule Klotho enhancers as novel treatment of neurodegeneration

31 August 2017

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KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer

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Therapeutic strategy for treatment of metastatic non-small cell lung cancer

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Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer

21 January 2018

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Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

21 January 2018

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Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549.

21 January 2018

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Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner

21 January 2018

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Elevated Klotho promoter methylation is associated with severity of chronic kidney disease

21 January 2018

1 reference

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Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

21 January 2018

1 reference

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Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression

21 January 2018

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Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

21 January 2018

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Regulation of angiogenesis by the aging suppressor gene klotho

21 January 2018

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The proliferating role of insulin and insulin-like growth factors in cancer

21 January 2018

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Role of Wnt canonical pathway in hematological malignancies

21 January 2018

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Targeting mutant fibroblast growth factor receptors in cancer

21 January 2018

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Klotho as a potential biomarker and therapy for acute kidney injury

21 January 2018

1 reference

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Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

21 January 2018

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PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy

21 January 2018

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Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

21 January 2018

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Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology

21 January 2018

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BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer

21 January 2018

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Clinical results with the DNA hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in patients with myelodysplastic syndromes: an update

21 January 2018

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21 January 2018

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Identification of novel small molecules that elevate Klotho expression

21 January 2018

1 reference

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A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease

21 January 2018

1 reference

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Wnt signalling and its impact on development and cancer

21 January 2018

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21 January 2018

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21 January 2018

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

1 reference

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Suppression of aging in mice by the hormone Klotho

21 January 2018

1 reference

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The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

21 January 2018

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Liver-specific activities of FGF19 require Klotho beta

21 January 2018

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Augmented Wnt signaling in a mammalian model of accelerated aging

21 January 2018

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Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Overexpression of klotho protein modulates uninephrectomy-induced compensatory renal hypertrophy by suppressing IGF-I signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma

21 January 2018

1 reference

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Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372

21 January 2018

1 reference

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Defining the pathway to insulin-like growth factor system targeting in cancer

21 January 2018

1 reference

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Epigenetic silencing of the tumor suppressor klotho in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Fibroblast growth factor signalling: from development to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho converts canonical FGF receptor into a specific receptor for FGF23

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho sensitizes human lung cancer cell line to cisplatin via PI3k/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Regulation of oxidative stress by the anti-aging hormone klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

βKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3β/cyclin D1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-014-1788-Y

Sequence, structural, functional, and phylogenetic analyses of three glycosidase families

21 January 2018

1 reference

12 December 2020

[DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance].

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12 December 2020

Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression

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12 December 2020

Klotho is silenced through promoter hypermethylation in gastric cancer.

1 reference

12 December 2020

Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients

1 reference

12 December 2020

Role of microRNAs in chronic lymphocytic leukemia (Review).

1 reference

12 December 2020

Wnt signaling and cancer

1 reference

12 December 2020

Klotho inhibits the capacity of cell migration and invasion in cervical cancer

1 reference

12 December 2020

KLOTHO methylation is linked to uremic toxins and chronic kidney disease

1 reference

12 December 2020

Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations

1 reference

12 December 2020

Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3β/Snail signaling in renal cell carcinoma

1 reference

12 December 2020

Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage

1 reference

12 December 2020

Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells

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12 December 2020

The prognostic significance of angiogenesis in epithelial ovarian carcinoma.

1 reference

12 December 2020

Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression

1 reference

12 December 2020

10.1007/S00432-014-1788-Y

Identifiers

DOI

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31 August 2017

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