Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development (Q38246625)

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scientific article published on September 2014

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English	Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development	scientific article published on September 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

1 reference

Europe PubMed Central

Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

obsessive-compulsive disorder

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Marco Grados

1

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Hyung Mo Sung

2

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Europe PubMed Central

PubMed publication ID

1 September 2017

Sejin Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Siddharth Srivastava

4

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

publication date

1 September 2014

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Europe PubMed Central

PubMed publication ID

1 September 2017

Drug Development Research

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Europe PubMed Central

PubMed publication ID

1 September 2017

75

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

372-383

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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GDNF, NGF and BDNF as therapeutic options for neurodegeneration.

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Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder

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An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool

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Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder.

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Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.

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The role of intracellular calcium stores in synaptic plasticity and memory consolidation

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Brain Derived Neurotrophic Factor: a novel neurotrophin involved in psychiatric and neurological disorders

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Rapamycin and mTOR kinase inhibitors

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Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning

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Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume

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Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

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Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity

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Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

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Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly

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Evolving neurobiology of tuberous sclerosis complex

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Behavioral tagging of extinction learning

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Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

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Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

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A neurotrophic model for stress-related mood disorders

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Activity-dependent neuronal signalling and autism spectrum disorder

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Inhibition of mTOR kinase via rapamycin blocks persistent predator stress-induced hyperarousal

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Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas.

1 reference

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21 January 2018

Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus

1 reference

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PTEN: A master regulator of neuronal structure, function, and plasticity

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Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders

1 reference

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21 January 2018

The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery

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Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach

1 reference

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ANI inactivation: unconditioned anxiolytic effects of anisomycin in the ventral hippocampus

1 reference

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TSC1/TSC2 signaling in the CNS.

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Restricted and repetitive behaviors in autism spectrum disorders and typical development: cross-sectional and longitudinal comparisons

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Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

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mTOR signaling: at the crossroads of plasticity, memory and disease

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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

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Effects of BDNF polymorphisms on brain function and behavior in health and disease.

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Local effects of BDNF on dendritic growth

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Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity

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Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

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Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus.

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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

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Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory.

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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor

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Immunosuppression using the mammalian target of rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement

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Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation.

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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

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Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

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Learning and reconsolidation implicate different synaptic mechanisms

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https://api.crossref.org/works/10.1002%2FDDR.21223

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Learning deficit in BDNF mutant mice

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Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease

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Do the dissociative side effects of ketamine mediate its antidepressant effects?

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Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory

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Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder

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https://api.crossref.org/works/10.1002%2FDDR.21223

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Cooperation between BDNF and glutamate in the regulation of synaptic transmission and neuronal development.

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Synaptic plasticity and memory: an evaluation of the hypothesis

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BTBD3 controls dendrite orientation toward active axons in mammalian neocortex

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Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

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Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor

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Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism?

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The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology

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Homeobox genes in obsessive-compulsive disorder

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Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior

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Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo

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BDNF mechanisms in late LTP formation: A synthesis and breakdown.

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Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

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Trk receptors: mediators of neurotrophin action

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Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.

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Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models

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Selectivity in neurotrophin signaling: theme and variations

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

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Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1.

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21 January 2018

Genome-wide association study of obsessive-compulsive disorder.

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21 January 2018

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Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects

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Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

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21 January 2018

Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis

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Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization

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mTOR signaling and its roles in normal and abnormal brain development

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Measurement methods of BDNF levels in major depression: a qualitative systematic review of clinical trials

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21 January 2018

Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder

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The role of the brain-derived neurotrophic factor SNP rs2883187 in the phenotypic expression of obsessive-compulsive disorder

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Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.

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Consolidation and reconsolidation of incentive learning in the amygdala.

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Brain-derived neurotrophic factor (BDNF) plasma levels in drug-naïve OCD patients are lower than those in healthy people, but are not lower than those in drug-treated OCD patients

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Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.

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Changes in alternative brain-derived neurotrophic factor transcript expression in the developing human prefrontal cortex

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Neuronal release of proBDNF.

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Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development

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Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway

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21 January 2018

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

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Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome.

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Neurons and tumor suppressors

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Association Testing of the Positional and Functional Candidate Gene SLC1A1/EAAC1 in Early-Onset Obsessive-compulsive Disorder

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands

1 reference

https://api.crossref.org/works/10.1002%2FDDR.21223

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/DDR.21223

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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