Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity. (Q38315813)

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scientific article published on 06 May 2013

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English	Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.	scientific article published on 06 May 2013

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29 February 2020

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity (English)

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Frédéric Checler

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Cristine Alves da Costa

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J Viotti

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C Caillava

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J Condat

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T Goiran

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C Giordano

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Y Marie

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J-Y Delattre

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J Honnorat

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29 February 2020

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p53: 25 years of research and more questions to answer.

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The p53 knowledgebase: an integrated information resource for p53 research.

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Direct transactivation of c-Ha-Ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis

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Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

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Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.

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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

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p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells

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Parkin gene alterations in hepatocellular carcinoma

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Pathogenic mutations inactivate parkin by distinct mechanisms.

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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

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Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer

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Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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p53 and brain tumors: from gene mutations to gene therapy

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Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

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10.1038/ONC.2013.124

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29 February 2020

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