Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. (Q40269778)

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29 January 2020

title

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease (English)

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29 January 2020

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10

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29 January 2020

Cristine Alves da Costa

1

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Peter Henry St George-Hyslop

29 January 2020

9

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2

Claire Sunyach

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29 January 2020

author name string

Raphaelle Pardossi-Piquard

3

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29 January 2020

Jean Sévalle

4

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29 January 2020

Bruno Vincent

5

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29 January 2020

Nicole Boyer

6

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29 January 2020

Nadège Girardot

8

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29 January 2020

Toshitaka Kawarai

7

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language of work or name

English

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publication date

1 June 2006

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29 January 2020

published in

Journal of Neuroscience

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29 January 2020

volume

26

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29 January 2020

page(s)

6377-6385

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29 January 2020

issue

23

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

29 January 2020

cites work

1 reference

12 December 2020

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

12 December 2020

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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12 December 2020

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

1 reference

12 December 2020

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

12 December 2020

Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

12 December 2020

p53-independent functions of the p19(ARF) tumor suppressor

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons.

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12 December 2020

Direct transcriptional activation of human caspase-1 by tumor suppressor p53.

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12 December 2020

The p53 tumor suppressor: critical regulator of life & death in cancer

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

12 December 2020

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

12 December 2020

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

12 December 2020

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

1 reference

12 December 2020

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

12 December 2020

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

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12 December 2020

gamma-Secretase inhibitors as molecular probes of presenilin function

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12 December 2020

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 December 2020

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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12 December 2020

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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12 December 2020

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

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12 December 2020

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

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12 December 2020

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

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12 December 2020

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

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12 December 2020

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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12 December 2020

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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12 December 2020

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

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12 December 2020

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

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12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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12 December 2020

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

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12 December 2020

[Neuronal DNA damage correlates with a positive detection of c-Jun, nuclear factor kB, p53 and Par-4 transcription factors in Alzheimer's disease]

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12 December 2020

Definition of a consensus binding site for p53

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12 December 2020

Attenuation of the p53 response to DNA damage by high cell density

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12 December 2020

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

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12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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12 December 2020

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

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12 December 2020

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

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12 December 2020

Identification of distinct gamma-secretase complexes with different APH-1 variants

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12 December 2020

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

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12 December 2020

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

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12 December 2020

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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12 December 2020

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

1 reference

12 December 2020

Neprilysin activity and expression are controlled by nicastrin

1 reference

12 December 2020

Protein-binding elements in the promoter region of the mouse p53 gene

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12 December 2020

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

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12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

12 December 2020

A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.

1 reference

12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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12 December 2020

Changes of p53 in the brains of patients with Alzheimer's disease.

1 reference

12 December 2020

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

12 December 2020

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

1 reference

12 December 2020

Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells

1 reference

12 December 2020

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

1 reference

12 December 2020

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

12 December 2020

Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.

1 reference

12 December 2020

10.1523/JNEUROSCI.0651-06.2006

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