Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses (Q38360625)

2 September 2017

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses (English)

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2 September 2017

Susumu Itoh

1

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2 September 2017

Midory Thorikay

2

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2 September 2017

Marcin Kowanetz

3

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2 September 2017

Aristidis Moustakas

4

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2 September 2017

Fumiko Itoh

5

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2 September 2017

Carl-Henrik Heldin

6

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2 September 2017

Peter ten Dijke

7

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2 September 2017

language of work or name

English

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publication date

22 November 2002

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

278

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2 September 2017

6

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2 September 2017

3751-3761

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TGFbeta signaling in growth control, cancer, and heritable disorders

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Mechanism of activation of the TGF-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Determinants of specificity in TGF-beta signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Regulation of cell proliferation by Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smads bind directly to the Jun family of AP-1 transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Chimeric granulocyte/macrophage colony-stimulating factor/transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Characterization of human FAST-1, a TGF beta and activin signal transducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Regulation of Smad signaling by protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A simplified system for generating recombinant adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF beta signals through a heteromeric protein kinase receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

The stress-activated protein kinase subfamily of c-Jun kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Phosphorylation regulation of the interaction between Smad7 and activin type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

Early endosomal regulation of Smad-dependent signaling in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208258200

21 January 2018

Identifiers

DOI

10.1074/JBC.M208258200

1 reference

2 September 2017

1 reference