NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers (Q38453895)

3 September 2017

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title

NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers (English)

1 reference

3 September 2017

Anne-Kathrin Claes

1

1 reference

PubMed ID

25933824

3 September 2017

Jun Yu Zhou

series ordinal

2

1 reference

PubMed ID

25933824

3 September 2017

Dana J Philpott

series ordinal

3

1 reference

3 September 2017

1 May 2015

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3 September 2017

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3 September 2017

30

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3 September 2017

241-250

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3 September 2017

3

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

3 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

CARD15/NOD2 is required for Peyer's patches homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Regulation of intestinal microbiota by the NLR protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Innate immune response to Salmonella typhimurium, a model enteric pathogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Salmonella enterica serovar Typhimurium ΔmsbB triggers exacerbated inflammation in Nod2 deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

New insights into the regulation of signalling by toll-like receptors and nod-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Function of Nod-like receptors in microbial recognition and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

No association between the functional CARD4 insertion/deletion polymorphism and inflammatory bowel diseases in the German population

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Identification of an innate T helper type 17 response to intestinal bacterial pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Critical functions of priming and lysosomal damage for NLRP3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NODs: intracellular proteins involved in inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Signal transduction pathways used by NLR-type innate immune receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Innate immune sensing of microbes by Nod proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Role for erbin in bacterial activation of Nod2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Mechanisms and functions of inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

L-Ala-γ-D-Glu-meso-diaminopimelic acid (DAP) interacts directly with leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its int

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Using Salmonella enterica serotype typhimurium to model intestinal fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod2 is required for the regulation of commensal microbiota in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod2 is essential for temporal development of intestinal microbial communities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The intestinal epithelial barrier in the control of homeostasis and immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Mouse Paneth cell antimicrobial function is independent of Nod2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Inflammatory caspases are innate immune receptors for intracellular LPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Inflammasomes: too big to miss

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Mechanism of NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The NLRP12 inflammasome recognizes Yersinia pestis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00025.2014

10.1152/PHYSIOL.00025.2014

21 January 2018

Identifiers

DOI

1 reference

3 September 2017

1 reference

PubMed ID

25933824