Glioblastoma: pathology, molecular mechanisms and markers (Q38460865)

3 September 2017

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title

Glioblastoma: pathology, molecular mechanisms and markers (English)

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3 September 2017

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5

Andreas von Deimling

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Guido Reifenberger

series ordinal

4

object named as

Guido Reifenberger

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3 September 2017

Kenneth Aldape

1

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3 September 2017

Gelareh Zadeh

series ordinal

2

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3 September 2017

Sheila Mansouri

series ordinal

3

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3 September 2017

language of work or name

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6 May 2015

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3 September 2017

published in

Acta Neuropathologica

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3 September 2017

volume

129

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3 September 2017

issue

6

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3 September 2017

page(s)

829-848

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Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

3 September 2017

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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TP53 Gene Mutations and 17p Deletions in Human Astrocytomas

21 January 2018

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A human brain tumor-derived PDGFR-alpha deletion mutant is transforming

21 January 2018

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IDH mutations in glioma and acute myeloid leukemia

21 January 2018

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RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation

21 January 2018

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Platelet-derived growth factor and its receptor expression in human oligodendrogliomas

21 January 2018

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Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

21 January 2018

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MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma

21 January 2018

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Signal transduction inhibition: results from phase I clinical trials in chronic myeloid leukemia

21 January 2018

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Regulation of the human telomerase reverse transcriptase gene

21 January 2018

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Emerging insights into the molecular and cellular basis of glioblastoma

21 January 2018

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Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

The integrated landscape of driver genomic alterations in glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Gene expression profiling of gliomas strongly predicts survival

21 January 2018

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Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma

21 January 2018

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IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma.

21 January 2018

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TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours.

21 January 2018

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 January 2018

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Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1).

21 January 2018

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Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity

21 January 2018

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Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma

21 January 2018

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

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Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.

21 January 2018

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Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03.

21 January 2018

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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

TERT promoter mutations in familial and sporadic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Amplification of Epidermal Growth Factor Receptor Gene in Gliomas: Histopathology and Prognosis

21 January 2018

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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

21 January 2018

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Genomic imprinting mechanisms in mammals.

21 January 2018

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

21 January 2018

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International network of cancer genome projects

21 January 2018

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Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology

21 January 2018

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Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours

21 January 2018

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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

21 January 2018

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Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Different angiogenic phenotypes in primary and secondary glioblastomas

21 January 2018

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

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Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

21 January 2018

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Epithelioid GBMs show a high percentage of BRAF V600E mutation.

21 January 2018

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Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.

21 January 2018

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Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.

21 January 2018

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Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

21 January 2018

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Long-term survival with glioblastoma multiforme

21 January 2018

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

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Pten haploinsufficiency accelerates formation of high-grade astrocytomas

21 January 2018

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Clinicopathologic and genomic features of gliosarcomas.

21 January 2018

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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

21 January 2018

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Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes

21 January 2018

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Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

21 January 2018

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Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

21 January 2018

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Expanding chemical biology of 2-oxoglutarate oxygenases

21 January 2018

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The 2007 WHO classification of tumours of the central nervous system

21 January 2018

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Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome

21 January 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

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Profiling critical cancer gene mutations in clinical tumor samples

21 January 2018

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Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial

21 January 2018

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Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

21 January 2018

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Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

21 January 2018

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Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis

21 January 2018

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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

21 January 2018

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Promoter hypermethylation of the RB1 gene in glioblastomas.

21 January 2018

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Corrigendum: Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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DNA methylation and chromatin modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

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The definition of primary and secondary glioblastoma

21 January 2018

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Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis.

21 January 2018

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CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.

21 January 2018

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PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

21 January 2018

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Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma

21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Addressing diffuse glioma as a systemic brain disease with single-cell analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

A vaccine targeting mutant IDH1 induces antitumour immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Gene expression profiling identifies molecular subtypes of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Pediatric glioblastomas: a histopathological and molecular genetic study

21 January 2018

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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

21 January 2018

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Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma

21 January 2018

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Epidemiologic and molecular prognostic review of glioblastoma

21 January 2018

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Distinct transcription profiles of primary and secondary glioblastoma subgroups.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.

21 January 2018

1 reference

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MGMT-STP27 methylation status as predictive marker for response to PCV in anaplastic Oligodendrogliomas and Oligoastrocytomas. A report from EORTC study 26951.

21 January 2018

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

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Frequency of TERT promoter mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Structural alterations of the epidermal growth factor receptor gene in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-015-1432-1

10.1007/S00401-015-1432-1

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

3 September 2017

1029275913

0 references

1 reference