Towards a molecular understanding of microRNA-mediated gene silencing (Q38528410)

3 September 2017

1 reference

title

Towards a molecular understanding of microRNA-mediated gene silencing (English)

1 reference

3 September 2017

0 references

1 reference

2

Elisa Izaurralde

1 reference

3 September 2017

Stefanie Jonas

1

0 references

publication date

16 June 2015

1 reference

3 September 2017

Nature Reviews Genetics

1 reference

3 September 2017

16

1 reference

3 September 2017

421-433

1 reference

3 September 2017

7

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg3965

3 September 2017

0 references

cites work

Diversifying microRNA sequence and function

1 reference

Most mammalian mRNAs are conserved targets of microRNAs

31 March 2020

1 reference

MicroRNA maturation and human disease.

31 March 2020

1 reference

From guide to target: molecular insights into eukaryotic RNA-interference machinery.

31 March 2020

1 reference

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

31 March 2020

1 reference

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

31 March 2020

1 reference

Regulation of microRNA biogenesis

31 March 2020

1 reference

Widespread changes in protein synthesis induced by microRNAs

31 March 2020

1 reference

The impact of microRNAs on protein output

31 March 2020

1 reference

Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA

31 March 2020

1 reference

Mammalian microRNAs predominantly act to decrease target mRNA levels

31 March 2020

1 reference

Poly(A)-tail profiling reveals an embryonic switch in translational control

31 March 2020

1 reference

mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues

31 March 2020

1 reference

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

31 March 2020

1 reference

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

31 March 2020

1 reference

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

31 March 2020

1 reference

Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs

31 March 2020

1 reference

MicroRNAs direct rapid deadenylation of mRNA

31 March 2020

1 reference

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

31 March 2020

1 reference

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

31 March 2020

1 reference

Deadenylation is a widespread effect of miRNA regulation

31 March 2020

1 reference

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

31 March 2020

1 reference

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

31 March 2020

1 reference

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

31 March 2020

1 reference

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

31 March 2020

1 reference

miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

31 March 2020

1 reference

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

31 March 2020

1 reference

Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins

31 March 2020

1 reference

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing

31 March 2020

1 reference

Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression

31 March 2020

1 reference

RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes.

31 March 2020

1 reference

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

31 March 2020

1 reference

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation

31 March 2020

1 reference

TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications

31 March 2020

1 reference

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system

31 March 2020

1 reference

Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

31 March 2020

1 reference

PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro

31 March 2020

1 reference

MicroRNAs mediate gene silencing via multiple different pathways in drosophila

31 March 2020

1 reference

Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish

31 March 2020

1 reference

miRNA repression of translation in vitro takes place during 43S ribosomal scanning.

31 March 2020

1 reference

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.

31 March 2020

1 reference

Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling

31 March 2020

1 reference

A brain-specific microRNA regulates dendritic spine development

31 March 2020

1 reference

Identification of novel argonaute-associated proteins

31 March 2020

1 reference

Disruption of GW bodies impairs mammalian RNA interference

31 March 2020

1 reference

A role for the P-body component GW182 in microRNA function

31 March 2020

1 reference

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

31 March 2020

1 reference

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

31 March 2020

1 reference

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

31 March 2020

1 reference

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

31 March 2020

1 reference

A C-terminal silencing domain in GW182 is essential for miRNA function

31 March 2020

1 reference

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

31 March 2020

1 reference

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

31 March 2020

1 reference

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

31 March 2020

1 reference

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

31 March 2020

1 reference

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

31 March 2020

1 reference

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

31 March 2020

1 reference

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.

31 March 2020

1 reference

The Crystal Structure of Human Argonaute2

31 March 2020

1 reference

Structural features of Argonaute-GW182 protein interactions

31 March 2020

1 reference

Structural basis for microRNA targeting

31 March 2020

1 reference

The Structure of Human Argonaute-2 in Complex with miR-20a

31 March 2020

1 reference

Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway

31 March 2020

1 reference

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein

31 March 2020

1 reference

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

31 March 2020

1 reference

The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase

31 March 2020

1 reference

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

31 March 2020

1 reference

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

31 March 2020

1 reference

Translational repression by deadenylases

31 March 2020

1 reference

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

31 March 2020

1 reference

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

31 March 2020

1 reference

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

31 March 2020

1 reference

Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction

31 March 2020

1 reference

The DHH1/RCKp54 family of helicases: an ancient family of proteins that promote translational silencing

31 March 2020

1 reference

The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

31 March 2020

1 reference

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

31 March 2020

1 reference

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

31 March 2020

1 reference

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

31 March 2020

1 reference

Regulation of poly(A)-binding protein through PABP-interacting proteins.

31 March 2020

1 reference

Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression

31 March 2020

1 reference

microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells

31 March 2020

1 reference

Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

31 March 2020

1 reference

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

31 March 2020

1 reference

Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.

31 March 2020

1 reference

Inhibition of translational initiation by Let-7 MicroRNA in human cells

31 March 2020

1 reference

MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

31 March 2020

1 reference

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

31 March 2020

1 reference

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.

31 March 2020

1 reference

Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

31 March 2020

1 reference

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

31 March 2020

1 reference

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

31 March 2020

1 reference

miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

31 March 2020

1 reference

Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation

31 March 2020

1 reference

Co-translational mRNA decay in Saccharomyces cerevisiae

31 March 2020

1 reference

MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila.

31 March 2020

1 reference

Functionally diverse microRNA effector complexes are regulated by extracellular signaling

31 March 2020

1 reference

Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing

31 March 2020

1 reference

The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs

31 March 2020

1 reference

The mechanism of eukaryotic translation initiation and principles of its regulation

31 March 2020

1 reference

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

31 March 2020

1 reference

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.

31 March 2020

1 reference

Short RNAs repress translation after initiation in mammalian cells.

31 March 2020

1 reference

eIF4GI facilitates the MicroRNA-mediated gene silencing

31 March 2020

1 reference

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

31 March 2020

1 reference

Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions

31 March 2020

1 reference

Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B

31 March 2020

1 reference

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

31 March 2020

1 reference

Structural Basis of Dcp2 Recognition and Activation by Dcp1

31 March 2020

1 reference

A proteome-scale map of the human interactome network

31 March 2020

1 reference

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

31 March 2020

1 reference

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

31 March 2020

1 reference

Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets

31 March 2020

1 reference

The role of GW182 proteins in miRNA-mediated gene silencing

31 March 2020

1 reference

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

31 March 2020

1 reference

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG3965

1 reference

PubMed ID

26077373

Dimensions Publication ID

3 September 2017

0 references

1 reference

PubMed ID

26077373