Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease (Q36846919)

16 August 2017

1 reference

title

Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease (English)

1 reference

16 August 2017

Lauren M Aleksunes

1

1 reference

PubMed ID

17562481

16 August 2017

José E Manautou

series ordinal

2

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PubMed ID

17562481

16 August 2017

language of work or name

English

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publication date

1 June 2007

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16 August 2017

Toxicologic Pathology

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16 August 2017

35

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16 August 2017

4

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16 August 2017

459-473

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

16 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

21 January 2018

Hepatic iron metabolism.

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The GI-GPx gene is a target for Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Tissue-specific functions of individual glutathione peroxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Role of NRF2 in protection against hyperoxic lung injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 defends the lung from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Fos and Jun: the AP-1 connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Alcohol and oxidative liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Microarray analysis of hepatic gene expression in gallstone-susceptible and gallstone-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

21 January 2018

Glutathione transferases

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Intracellular signaling mechanisms of acetaminophen-induced liver cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nuclear import and export signals in control of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 signaling in coordinated activation of antioxidant gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Molecular mechanism of nrf2 activation by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

CYP2E1: Biochemistry, Toxicology, Regulation and Function in Ethanol-Induced Liver Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Regulation of hepatic transporters by xenobiotic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The role of oxidative stress in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Electron paramagnetic resonance for small animal imaging applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2, a multi-organ protector?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Glutathione S-transferase polymorphisms: cancer incidence and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Lethal effect of the anti-Fas antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Diverse antioxidants protect against acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Quinone reductases multitasking in the metabolic world

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Updates on acetaminophen toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Apoptosis signaling by death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Pentachlorophenol (PCP) produces liver oxidative stress and promotes but does not initiate hepatocarcinogenesis in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

The Nrf2-ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Functional antioxidant responsive elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

kelch encodes a component of intercellular bridges in Drosophila egg chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Identification of polymorphisms in the promoter region of the human NRF2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Functional characterization of transcription regulators that interact with the electrophile response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230701311344

10.1080/01926230701311344

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17562481