The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects (Q38581311)

4 September 2017

The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects (English)

1 reference

4 September 2017

Yeon Hee Ban

1

1 reference

PubMed ID

26342319

4 September 2017

Sung Ryeol Park

series ordinal

2

1 reference

PubMed ID

26342319

4 September 2017

Yeo Joon Yoon

series ordinal

3

1 reference

4 September 2017

5 September 2015

1 reference

Journal of Industrial Microbiology & Biotechnology

4 September 2017

1 reference

4 September 2017

43

1 reference

4 September 2017

2-3

1 reference

4 September 2017

389-400

1 reference

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

4 September 2017

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Biosynthesis of polyketide synthase extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Steps towards the synthetic biology of polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Origin of the allyl group in FK506 biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

The mechanism of action of cyclosporin A and FK506.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Strain development of Streptomyces sp. for tacrolimus production using sequential adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Discovery of FK-506 and update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Nerve repair by means of tubulization: past, present, future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Novel chemobiosynthetic approach for exclusive production of FK506.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Roles of type II thioesterases and their application for secondary metabolite yield improvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Immunosuppression: evolution in practice and trends, 1994-2004.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

FK-506--a novel immunosuppressant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Regulation of tacrolimus production by altering primary source of carbons and amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Cyclosporin A. Clinical pharmacology and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-015-1677-7

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

21 January 2018

1 reference

12 December 2020

Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011

1 reference

12 December 2020

Lipase activity and tacrolimus production in Streptomyces clavuligerus CKD 1119 mutant strains.

1 reference

12 December 2020

Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis

1 reference

12 December 2020

Chemical and biological characterization of two FK506 analogs produced by targeted gene disruption in Streptomyces sp. MA6548.

1 reference

12 December 2020

The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury

1 reference

12 December 2020

SnapShot: Ca2+-calcineurin-NFAT signaling

1 reference

12 December 2020

Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.

1 reference

12 December 2020

FK506 and nerve regeneration: past, present, and future

1 reference

12 December 2020

Prolongation of skin allograft survival in rats by a novel immunosuppressive agent, FK506

1 reference

12 December 2020

Chemical and Biological Characterization of Two FK506 Analogs Produced by Targeted Gene Disruption in Streptomyces sp. MA6548.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.50.418

Identifiers

DOI

10.1007/S10295-015-1677-7

1 reference

4 September 2017

1 reference

PubMed ID

26342319