Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein (Q38669105)

5 September 2017

title

Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein (English)

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5 September 2017

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1

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9 June 2020

author name string

S George

series ordinal

2

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9 June 2020

P Brundin

series ordinal

3

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9 June 2020

publication date

15 December 2015

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Neuropathology and Applied Neurobiology

5 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26666838%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

42

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9 June 2020

issue

1

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9 June 2020

page(s)

51-76

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

9 June 2020

cites work

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The transcellular spread of cytosolic amyloids, prions, and prionoids

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Tau promotes neurodegeneration through global chromatin relaxation

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Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease

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Staging of brain pathology related to sporadic Parkinson's disease

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

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Stages in the development of Parkinson's disease-related pathology

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Prion-like spreading of pathological α-synuclein in brain

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Alpha-synuclein transfers from neurons to oligodendrocytes

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Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies

21 January 2018

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Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

21 January 2018

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Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

21 January 2018

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A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders

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Neuropathology underlying clinical variability in patients with synucleinopathies

21 January 2018

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Multiple system atrophy: a clinical and neuropathological perspective

21 January 2018

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Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

21 January 2018

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Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease.

21 January 2018

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Wildtype and A30P mutant alpha-synuclein form different fibril structures

21 January 2018

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The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

21 January 2018

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

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Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

21 January 2018

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Structure of the toxic core of α-synuclein from invisible crystals

21 January 2018

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Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations

21 January 2018

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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

21 January 2018

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Detecting morphologically distinct oligomeric forms of alpha-synuclein

21 January 2018

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered

21 January 2018

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The Parkinson's complex: parkinsonism is just the tip of the iceberg

21 January 2018

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A timeline for Parkinson's disease

21 January 2018

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Neuropathobiology of non-motor symptoms in Parkinson disease

21 January 2018

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Poor and protracted myelination as a contributory factor to neurodegenerative disorders

21 January 2018

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Parkinson's disease: a dual-hit hypothesis

21 January 2018

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Parkinson's disease: the dual hit theory revisited

21 January 2018

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The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging

21 January 2018

1 reference

A critical evaluation of the Braak staging scheme for Parkinson's disease.

21 January 2018

1 reference

Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

1 reference

Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance

21 January 2018

1 reference

The Lewy body in Parkinson's disease and related neurodegenerative disorders

21 January 2018

1 reference

Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts

21 January 2018

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Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study

21 January 2018

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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

1 reference

Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?

21 January 2018

1 reference

Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?

21 January 2018

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Accumulation of phosphorylated alpha-synuclein in aging human brain

21 January 2018

1 reference

Vagotomy and subsequent risk of Parkinson's disease

21 January 2018

1 reference

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

21 January 2018

1 reference

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers

21 January 2018

1 reference

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

21 January 2018

1 reference

Staged pathology in Parkinson's disease

21 January 2018

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Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient

21 January 2018

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Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium.

21 January 2018

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

21 January 2018

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Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb

21 January 2018

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Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.

21 January 2018

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Lewy body pathology involves cutaneous nerves

21 January 2018

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Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

The role of alpha-synuclein in the pathogenesis of multiple system atrophy

21 January 2018

1 reference

Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy.

21 January 2018

1 reference

Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease

21 January 2018

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Genetic variants and animal models in SNCA and Parkinson disease.

21 January 2018

1 reference

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

21 January 2018

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Link between the SNCA gene and parkinsonism

21 January 2018

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Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia

21 January 2018

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Alpha-synuclein mRNA expression in oligodendrocytes in MSA.

21 January 2018

1 reference

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

21 January 2018

1 reference

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

21 January 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic

21 January 2018

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Propagating prions in fungi and mammals

21 January 2018

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Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

21 January 2018

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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

21 January 2018

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Can Parkinson's disease pathology be propagated from one neuron to another?

21 January 2018

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Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

21 January 2018

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Alpha-synuclein spreading in Parkinson's disease

21 January 2018

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Caudo-rostral brain spreading of α-synuclein through vagal connections

21 January 2018

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Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

21 January 2018

1 reference

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

21 January 2018

1 reference

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

21 January 2018

1 reference

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

21 January 2018

1 reference

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

21 January 2018

1 reference

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

21 January 2018

1 reference

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

21 January 2018

1 reference

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

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Pathological alpha-synuclein propagates through neural networks

21 January 2018

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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

21 January 2018

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

21 January 2018

1 reference

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

21 January 2018

1 reference

Alpha-synuclein and neurodegenerative diseases

21 January 2018

1 reference

Alpha-synuclein: normal function and role in neurodegenerative diseases.

21 January 2018

1 reference

Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

21 January 2018

1 reference

A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease

21 January 2018

1 reference

Alpha-synuclein and tau: teammates in neurodegeneration?

21 January 2018

1 reference

Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies

21 January 2018

1 reference

Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation.

21 January 2018

1 reference

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases

21 January 2018

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Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases

21 January 2018

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Distinct α-synuclein strains differentially promote tau inclusions in neurons

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

21 January 2018

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

21 January 2018

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Concentration dependence of alpha-synuclein fibril length assessed by quantitative atomic force microscopy and statistical-mechanical theory

21 January 2018

1 reference

Tissue transglutaminase modulates alpha-synuclein oligomerization

21 January 2018

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms

21 January 2018

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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

21 January 2018

1 reference

The Interplay between Alpha-Synuclein Clearance and Spreading

21 January 2018

1 reference

Prions: protein aggregation and infectious diseases

21 January 2018

1 reference

Could α-synuclein amyloid-like aggregates trigger a prionic neuronal invasion?

21 January 2018

1 reference

Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

21 January 2018

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Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease

21 January 2018

1 reference

Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies

21 January 2018

1 reference

Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

1 reference

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

21 January 2018

1 reference

Transmission of multiple system atrophy prions to transgenic mice

21 January 2018

1 reference

Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism

21 January 2018

1 reference

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

21 January 2018

1 reference

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

21 January 2018

1 reference

Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry

21 January 2018

1 reference

α-synuclein phosphorylation and truncation are normal events in the adult human brain

21 January 2018

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Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies

21 January 2018

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Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course

21 January 2018

1 reference

Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

21 January 2018

1 reference

Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects

21 January 2018

1 reference

Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy

21 January 2018

1 reference

Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions

21 January 2018

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Phosphorylation of synucleins by members of the Polo-like kinase family

21 January 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein

21 January 2018

1 reference

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice

21 January 2018

1 reference

Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice

21 January 2018

1 reference

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

21 January 2018

1 reference

Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

21 January 2018

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

21 January 2018

1 reference

Protein phosphorylation in neurodegeneration: friend or foe?

21 January 2018

1 reference

The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease

21 January 2018

1 reference

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

21 January 2018

1 reference

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.

21 January 2018

1 reference

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.

21 January 2018

1 reference

Phosphorylated α-synuclein in Parkinson's disease

21 January 2018

1 reference

Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity

21 January 2018

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Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

21 January 2018

1 reference

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

21 January 2018

1 reference

Protective effect of telmisartan against progressive oxidative brain damage and synuclein phosphorylation in stroke-resistant spontaneously hypertensive rats

21 January 2018

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Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis

21 January 2018

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Phosphorylated alpha-synuclein in normal mouse brain

21 January 2018

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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

21 January 2018

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Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

21 January 2018

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Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.

21 January 2018

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Biochemical characterization of the core structure of alpha-synuclein filaments

21 January 2018

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

21 January 2018

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Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain

21 January 2018

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Direct detection of alpha synuclein oligomers in vivo

21 January 2018

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Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.

21 January 2018

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Relationships between Lewy bodies and pale bodies in Parkinson's disease

21 January 2018

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Evaluation of alpha-synuclein immunohistochemical methods used by invited experts

21 January 2018

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Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease

21 January 2018

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

21 January 2018

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The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

21 January 2018

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Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

21 January 2018

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Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

21 January 2018

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p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions

21 January 2018

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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

21 January 2018

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Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

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Tau protein and tau aggregation inhibitors

21 January 2018

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α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system

21 January 2018

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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

21 January 2018

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Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.

21 January 2018

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Metastability of Native Proteins and the Phenomenon of Amyloid Formation

21 January 2018

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Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†

21 January 2018

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Distinctive neuropathology revealed by α-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/NAN.12299

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26666838%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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