Why cells need intramembrane proteases - a mechanistic perspective (Q38682929)

5 September 2017

title

Why cells need intramembrane proteases - a mechanistic perspective (English)

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5 September 2017

Kvido Strisovsky

1

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5 September 2017

language of work or name

English

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publication date

30 December 2015

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5 September 2017

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5 September 2017

volume

283

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5 September 2017

issue

10

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5 September 2017

page(s)

1837-1845

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

5 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Mechanisms and cellular functions of intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Bioinformatics perspective on rhomboid intramembrane protease evolution and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Molecular and cellular mechanisms of ectodomain shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Membrane-anchored serine proteases in vertebrate cell and developmental biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Membrane proteases in the bacterial protein secretion and quality control pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Update 1 of: Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Sequence features of substrates required for cleavage by GlpG, an Escherichia coli rhomboid protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

The intramembrane active site of GlpG, an E. coli rhomboid protease, is accessible to water and hydrolyses an extramembrane peptide bond of substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Structure and mechanism of intramembrane protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Architectural and thermodynamic principles underlying intramembrane protease function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Structural basis for intramembrane proteolysis by rhomboid serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

X-ray structure of a protein-conducting channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

A subset of membrane-altering agents and γ-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Post-liberation cleavage of signal peptides is catalyzed by the site-2 protease (S2P) in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Quality control of cytoplasmic membrane proteins in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Processing by rhomboid protease is required for Providencia stuartii TatA to interact with TatC and to form functional homo-oligomeric complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

A comprehensive comparison of transmembrane domains reveals organelle-specific properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Prediction of the human membrane proteome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Protein ectodomain shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Biochemical and structural insights into intramembrane metalloprotease mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Allosteric regulation of rhomboid intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

Sharpening rhomboid specificity by dimerisation and allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13638

21 January 2018

Identifiers

DOI

10.1111/FEBS.13638

1 reference

5 September 2017

1 reference