Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids (Q38083850)

28 August 2017

title

Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids (English)

1 reference

28 August 2017

1 reference

Kvido Strisovsky

1

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28 August 2017

language of work or name

English

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publication date

20 March 2013

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28 August 2017

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28 August 2017

volume

280

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28 August 2017

issue

7

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28 August 2017

page(s)

1579-1603

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Defining human ERAD networks through an integrative mapping strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid proteases and their biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The rhomboid protease family: a decade of progress on function and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Apicomplexan rhomboids have a potential role in microneme protein cleavage during host cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Plasmodium protease ROM1 is important for proper formation of the parasitophorous vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Topogenesis of membrane proteins at the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Update 1 of: Beta-strand mimetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Update 1 of: Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Recognition of transmembrane helices by the endoplasmic reticulum translocon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Sequence features of substrates required for cleavage by GlpG, an Escherichia coli rhomboid protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The intramembrane active site of GlpG, an E. coli rhomboid protease, is accessible to water and hydrolyses an extramembrane peptide bond of substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structural basis for intramembrane proteolysis by rhomboid serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Architectural and thermodynamic principles underlying intramembrane protease function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structure of Rhomboid Protease in a Lipid Environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Open-cap conformation of intramembrane protease GlpG

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Insights into substrate gating in H. influenzae rhomboid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The Role of L1 Loop in the Mechanism of Rhomboid Intramembrane Protease GlpG

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Rhomboid protease dynamics and lipid interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The structural basis for catalysis and substrate specificity of a rhomboid protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Multifaceted substrate capture scheme of a rhomboid protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structural basis of substrate specificity in the serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Serine protease mechanism and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structural and mechanistic basis of Parl activity and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Activity-based protein profiling of the Escherichia coli GlpG rhomboid protein delineates the catalytic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Insights into the effect of detergents on the full-length rhomboid protease from Pseudomonas aeruginosa and its cytosolic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Helical membrane protein folding, stability, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

YaeL (EcfE) activates the sigma(E) pathway of stress response through a site-2 cleavage of anti-sigma(E), RseA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The Bacillus subtilis sigmaW anti-sigma factor RsiW is degraded by intramembrane proteolysis through YluC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Degradation of the membrane-localized virulence activator TcpP by the YaeL protease in Vibrio cholerae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Expression of hurP, a gene encoding a prospective site 2 protease, is essential for heme-dependent induction of bhuR in Bordetella bronchiseptica

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Post-liberation cleavage of signal peptides is catalyzed by the site-2 protease (S2P) in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structure of a site-2 protease family intramembrane metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

FlaK of the archaeon Methanococcus maripaludis possesses preflagellin peptidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Cleavage of preflagellins by an aspartic acid signal peptidase is essential for flagellation in the archaeon Methanococcus voltae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The crystal structure of GXGD membrane protease FlaK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structure of a presenilin family intramembrane aspartate protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structural investigation of the C-terminal catalytic fragment of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Identification of an archaeal presenilin-like intramembrane protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Glu-333 of nicastrin directly participates in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

TOPCONS: consensus prediction of membrane protein topology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

Erratum: Crystal structure of a bacterialsignal peptidase in complex with a β-lactam inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12199

21 January 2018

Identifiers

DOI

10.1111/FEBS.12199

1 reference

28 August 2017

1 reference