A new era of disease modeling and drug discovery using induced pluripotent stem cells (Q38786732)

6 September 2017

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title

A new era of disease modeling and drug discovery using induced pluripotent stem cells (English)

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6 September 2017

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Wonhee Suh

1

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6 September 2017

publication date

5 December 2016

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Archives of Pharmacal Research

6 September 2017

published in

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6 September 2017

volume

40

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6 September 2017

issue

1

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6 September 2017

page(s)

1-12

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describes a project that uses

6 September 2017

induced pluripotent stem cell

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based on heuristic

inferred from title

cites work

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

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Pluripotent stem cells in disease modelling and drug discovery

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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

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Modelling schizophrenia using human induced pluripotent stem cells

21 January 2018

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A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

21 January 2018

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N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons

21 January 2018

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High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

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Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

21 January 2018

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Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

21 January 2018

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Lineage-specific biology revealed by a finished genome assembly of the mouse

21 January 2018

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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

21 January 2018

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Metabolism and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor apatinib in humans.

21 January 2018

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Induced pluripotent stem cells from a spinal muscular atrophy patient

21 January 2018

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Drug screening for ALS using patient-specific induced pluripotent stem cells

21 January 2018

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Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos

21 January 2018

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Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial

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Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells

21 January 2018

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

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VPA response in SMA is suppressed by the fatty acid translocase CD36.

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Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1.

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Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

21 January 2018

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Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration

21 January 2018

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Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei

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Clinical development success rates for investigational drugs

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The use of induced pluripotent stem cells in drug development

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iPS cells: a game changer for future medicine

21 January 2018

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Modelling the long QT syndrome with induced pluripotent stem cells

21 January 2018

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A nonviral minicircle vector for deriving human iPS cells

21 January 2018

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Modeling retinal degeneration using patient-specific induced pluripotent stem cells

21 January 2018

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Effect of RGD-immobilized dual-pore poly(L-lactic acid) scaffolds on chondrocyte proliferation and extracellular matrix production

21 January 2018

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Virus-free induction of pluripotency and subsequent excision of reprogramming factors

21 January 2018

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A guide to genome engineering with programmable nucleases

21 January 2018

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Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.

21 January 2018

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Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins

21 January 2018

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Cooperation of endothelial and smooth muscle cells derived from human induced pluripotent stem cells enhances neovascularization in dermal wounds

21 January 2018

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Positive correlation between the dysregulation of transforming growth factor-β1 and aneurysmal pathological changes in patients with Marfan syndrome

21 January 2018

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Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

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Early Lymph Vessel Development From Embryonic Stem Cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons

21 January 2018

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Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

21 January 2018

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Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Modeling human disease with pluripotent stem cells: from genome association to function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Generation of mouse induced pluripotent stem cells without viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Valproate reverts zinc and potassium imbalance in schizophrenia-derived reprogrammed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Market withdrawal of new molecular entities approved in the United States from 1980 to 2009

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

The promise of induced pluripotent stem cells in research and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

International coordination of large-scale human induced pluripotent stem cell initiatives: Wellcome Trust and ISSCR workshops white paper

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

HPGCD outperforms HPBCD as a potential treatment for Niemann-Pick disease type C during disease modeling with iPS cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Induced pluripotent stem cells generated without viral integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Neural differentiation of Fragile X human Embryonic Stem Cells reveals abnormal patterns of development despite successful neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Viable offspring derived from fetal and adult mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Treatment of Alzheimer disease and prognosis of dementia: time to translate research to results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Modeling familial Alzheimer's disease with induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Human induced pluripotent stem cells free of vector and transgene sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-016-0871-0

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10821

Identifiers

DOI

10.1007/S12272-016-0871-0

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Dimensions Publication ID

6 September 2017

1008564664

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1 reference