Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer (Q38798405)

6 September 2017

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title

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer (English)

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6 September 2017

Marco Barazas

2

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Sven Rottenberg

object named as

Sven Rottenberg

series ordinal

3

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author name string

Stefano Annunziato

series ordinal

1

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6 September 2017

Jos Jonkers

series ordinal

4

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6 September 2017

publication date

4 November 2016

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Cold Spring Harbor Symposia on Quantitative Biology

6 September 2017

published in

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6 September 2017

volume

81

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6 September 2017

page(s)

141-150

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Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies.

6 September 2017

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PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

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Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility

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The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

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Comprehensive molecular portraits of human breast tumours

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70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

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RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

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Replication fork stability confers chemoresistance in BRCA-deficient cells

21 January 2018

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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

21 January 2018

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Olaparib: first global approval

21 January 2018

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

21 January 2018

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Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

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Genomic Characterization of Primary Invasive Lobular Breast Cancer

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Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

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BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

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BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

21 January 2018

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Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 January 2018

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A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Organoids as an in vitro model of human development and disease.

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Patient-derived xenograft models: an emerging platform for translational cancer research

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Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

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Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

21 January 2018

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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.

21 January 2018

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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

21 January 2018

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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

21 January 2018

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Invasive lobular carcinoma of the breast: incidence and variants

21 January 2018

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Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

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Landscape of somatic mutations in 560 breast cancer whole-genome sequences

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The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

21 January 2018

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Whole-genome characterization of chemoresistant ovarian cancer.

21 January 2018

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Molecular portraits of human breast tumours

21 January 2018

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CRISPR-Cas9 knockin mice for genome editing and cancer modeling

21 January 2018

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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

21 January 2018

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

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Applications of the CRISPR-Cas9 system in cancer biology

21 January 2018

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CRISPR-Cas systems for editing, regulating and targeting genomes

21 January 2018

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Breast cancers with a BRCA1-like DNA copy number profile recur less often than expected after high-dose alkylating chemotherapy.

21 January 2018

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The landscape of cancer genes and mutational processes in breast cancer

21 January 2018

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Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

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Lineage tracing of mammary epithelial cells using cell-type-specific cre-expressing adenoviruses

21 January 2018

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https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

21 January 2018

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https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

Modelling breast cancer: one size does not fit all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

PTIP associates with Artemis to dictate DNA repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

53BP1 regulates DSB repair using Rif1 to control 5' end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2016.81.030924

10.1101/SQB.2016.81.030924

21 January 2018

Identifiers

DOI

1 reference

6 September 2017

1 reference