Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans (Q38827148)

6 September 2017

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans (English)

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6 September 2017

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4

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5 June 2020

Gavinella Latte

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Clay F. Semenkovich

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5 June 2020

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Lei Li

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Giulia M Pilo

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Xiaolei Li

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Li Che

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Christy Joseph

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Marta Mela

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Chunmei Wang

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Lijie Jiang

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Silvia Ribback

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Maria M Simile

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Rosa M Pascale

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Frank Dombrowski

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Matthias Evert

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Xin Chen

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Diego F Calvisi

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5 June 2020

language of work or name

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14 October 2015

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6 September 2017

Journal of Hepatology

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5 June 2020

volume

64

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issue

2

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5 June 2020

page(s)

333-341

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The effect of polyunsaturated fatty acids on obesity through epigenetic modifications.

5 June 2020

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9 September 2017

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9 September 2017

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Expression and roles of fatty acid synthase in hepatocellular carcinoma

9 September 2017

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4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice

9 September 2017

1 reference

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SREBP-1 has a prognostic role and contributes to invasion and metastasis in human hepatocellular carcinoma

9 September 2017

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Hydrodynamic transfection for generation of novel mouse models for liver cancer research

9 September 2017

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Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids

9 September 2017

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

9 September 2017

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Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

9 September 2017

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Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice

9 September 2017

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Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression

9 September 2017

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mTOR signaling in growth control and disease

9 September 2017

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Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

9 September 2017

1 reference

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Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

9 September 2017

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Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma

9 September 2017

1 reference

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Fatty acid synthase inhibitors: new directions for oncology

9 September 2017

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

9 September 2017

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Distinct pathways of genomic progression to benign and malignant tumors of the liver.

9 September 2017

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Fatty acid synthase and cancer: new application of an old pathway

9 September 2017

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Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

9 September 2017

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Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat.

9 September 2017

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

9 September 2017

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Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro

9 September 2017

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AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/

9 September 2017

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Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

9 September 2017

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14 September 2017

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Polymorphisms in genes of the de novo lipogenesis pathway and overall survival of hepatocellular carcinoma patients undergoing transarterial chemoembolization

14 September 2017

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Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma

25 September 2017

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17 June 2018

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22 August 2018

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22 August 2018

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22 August 2018

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