Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. (Q38875103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27339003%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

review article

1 reference

title

Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules (English)

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15 March 2020

1

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15 March 2020

author name string

Jie Zhou

2

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15 March 2020

Yue Zheng

3

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15 March 2020

Jianmei Su

4

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15 March 2020

Herman O Sintim

5

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15 March 2020

language of work or name

English

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publication date

24 June 2016

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15 March 2020

number of pages

16

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based on heuristic

inferred from page(s)

published in

Chemical Communications

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15 March 2020

volume

52

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15 March 2020

issue

60

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15 March 2020

page(s)

9327-9342

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Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.

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Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis

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Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection

21 January 2018

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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

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Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase

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Systematic identification of conserved bacterial c-di-AMP receptor proteins

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Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

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Complex structure and biochemical characterization of the Staphylococcus aureus cyclic diadenylate monophosphate (c-di-AMP)-binding protein PstA, the founding member of a new signal transduction protein family

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The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function

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Riboswitches in eubacteria sense the second messenger c-di-AMP

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The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis

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Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein

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Unexpected complex formation between coralyne and cyclic diadenosine monophosphate providing a simple fluorescent turn-on assay to detect this bacterial second messenger

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1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Nuclease-Resistant c-di-AMP Derivatives That Differentially Recognize RNA and Protein Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Control of bacterial exoelectrogenesis by c-AMP-GMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Intracellular DNA recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

STING recognition of cytoplasmic DNA instigates cellular defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

STING is a direct innate immune sensor of cyclic di-GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Bacterial c-di-GMP is an immunostimulatory molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6CC03439J

21 January 2018

Identifiers

DOI

10.1039/C6CC03439J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27339003%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference