The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop (Q27681456)

2

1 reference

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2 June 2020

Chad A Brautigam

7

1 reference

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2 June 2020

Zhijian J Chen

9

1 reference

ORCID Public Data File 2021

author name string

Xu Zhang

1

1 reference

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2 June 2020

Fenghe Du

3

1 reference

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2 June 2020

Hui Xu

4

1 reference

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2 June 2020

Lijun Sun

5

1 reference

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2 June 2020

Zhe Chen

6

1 reference

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2 June 2020

Xuewu Zhang

8

1 reference

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2 June 2020

publication date

13 February 2014

0 references

published in

Cell Reports

1 reference

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2 June 2020

volume

6

1 reference

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2 June 2020

page(s)

421-430

1 reference

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2 June 2020

issue

3

1 reference

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

2 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS

20 March 2017

1 reference

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

20 March 2017

1 reference

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Structural mechanism of cytosolic DNA sensing by cGAS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

20 March 2017

1 reference

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Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer

20 March 2017

1 reference

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Pattern recognition receptors and inflammation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Cytoplasmic DNA innate immune pathways

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

The structural basis for control of eukaryotic protein kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Sedimentation patterns of rapidly reversible protein interactions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

RNA recognition and signal transduction by RIG-I-like receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

RIGorous detection: exposing virus through RNA sensing.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969844

Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24462292

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.01.003

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462292%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

2 references

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2 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24462292%20AND%20SRC:MED&resulttype=core&format=json