The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage (Q38878664)

7 September 2017

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage (English)

1 reference

7 September 2017

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Ziv Porat

3

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author name string

Nina Reuven

1

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7 September 2017

Julia Adler

2

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7 September 2017

Tilman Polonio-Vallon

4

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7 September 2017

Thomas G Hofmann

5

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7 September 2017

Yosef Shaul

6

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7 September 2017

language of work or name

English

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publication date

5 May 2015

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Journal of Biological Chemistry

7 September 2017

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7 September 2017

290

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7 September 2017

27

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7 September 2017

16478-16488

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describes a project that uses

7 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4505402/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

9 September 2017

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9 September 2017

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PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation

9 September 2017

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9 September 2017

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9 September 2017

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The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

9 September 2017

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Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

9 September 2017

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

9 September 2017

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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

9 September 2017

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

9 September 2017

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

9 September 2017

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Mdm2 promotes the rapid degradation of p53

9 September 2017

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HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

9 September 2017

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The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

9 September 2017

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c-Abl phosphorylates Hdmx and regulates its interaction with p53.

9 September 2017

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A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage

9 September 2017

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An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

14 September 2017

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14 September 2017

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14 September 2017

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Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

14 September 2017

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Attenuation of the p53 response to DNA damage by high cell density

14 September 2017

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Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins

14 September 2017

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Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth

25 September 2017

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Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization.

17 June 2018

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The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl

22 August 2018

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HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

22 August 2018

1 reference

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Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth

22 August 2018

1 reference

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Dynamics of component exchange at PML nuclear bodies

22 August 2018

1 reference

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505402

Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505402

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505402

c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505402

Determination of cell fate by c-Abl activation in the response to DNA damage

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25944899

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Extended depth of field imaging for high speed cell analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25944899

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.628982

1 reference

7 September 2017

1 reference

7 September 2017

PubMed publication ID

25944899

1 reference