MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway (Q24337839)

15

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Francesca Mancini

1

0 references

Simona Giglio

6

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Silvia Soddu

14

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Marsha Pellegrino

object named as

Marsha Pellegrino

3

0 references

Cinzia Rinaldo

object named as

Cinzia Rinaldo

4

0 references

Igea D'Agnano

object named as

Igea D'Agnano

7

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author name string

Giusy Di Conza

2

0 references

Andrea Prodosmo

5

0 references

Fulvio Florenzano

8

0 references

Lara Felicioni

9

0 references

Fiamma Buttitta

10

0 references

Antonio Marchetti

11

0 references

Alfredo Pontecorvi

on focus list of Wikimedia project

13

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language of work or name

English

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publication date

8 July 2009

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published in

The EMBO Journal

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volume

28

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issue

13

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page(s)

1926-39

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ScienceSource

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cites work

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MDM2 interacts with MDMX through their RING finger domains

19 March 2017

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

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Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

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27 September 2017

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Stress-induced p53 runs a transcription-independent death program

27 September 2017

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

27 September 2017

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27 September 2017

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

27 September 2017

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

27 September 2017

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DNA damage-induced MDMX degradation is mediated by MDM2.

27 September 2017

1 reference

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MDM2 promotes ubiquitination and degradation of MDMX

27 September 2017

1 reference

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

27 September 2017

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

27 September 2017

1 reference

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

Stress signals utilize multiple pathways to stabilize p53

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

MdmX protects p53 from Mdm2-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

Mdm2 and Mdm4 loss regulates distinct p53 activities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.154

The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.154

21 January 2018

Mdm2: p53's lifesaver?

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.154

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.154

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711189

Hdmx stabilizes Mdm2 and p53

29 November 2018

1 reference

12 December 2020

mdmx is a negative regulator of p53 activity in vivo

1 reference

12 December 2020

Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets

1 reference

12 December 2020

Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues

1 reference

12 December 2020

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.154

1 reference

1 reference

1 reference

PubMed publication ID

19521340

1 reference