Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes (Q38888130)

7 September 2017

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes (English)

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7 September 2017

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7

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12

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7 September 2017

Karl Bacos

1

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Linn Gillberg

Linn Gillberg

2

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Torben Hansen

Torben Hansen

5

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Oluf Borbye Pedersen

Oluf Pedersen

6

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Charlotte Ling

Charlotte Ling

15

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Leif Groop

11

Leif Groop

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7 September 2017

10

Peter Almgren

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14

Tasnim Dayeh

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7 September 2017

Petr Volkov

3

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7 September 2017

Anders H Olsson

4

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7 September 2017

Hans Eiberg

8

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7 September 2017

Allan Vaag

13

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7 September 2017

language of work or name

English

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publication date

31 March 2016

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7 September 2017

Nature Communications

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7 September 2017

7

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7 September 2017

11089

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Creative Commons Attribution 4.0 International

7 September 2017

start time

31 March 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4821875/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4821875

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms11089

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cites work

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Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

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9 September 2017

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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

9 September 2017

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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue

9 September 2017

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Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

9 September 2017

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Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

9 September 2017

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Quantifying β-cells in health and disease: the past, the present, and the need

9 September 2017

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Genome-wide methylation profiles reveal quantitative views of human aging rates

9 September 2017

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9 September 2017

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9 September 2017

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Distinct DNA methylomes of newborns and centenarians

9 September 2017

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

9 September 2017

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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

9 September 2017

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Is genetic testing useful to predict type 2 diabetes?

9 September 2017

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Diabetes mellitus and the β cell: the last ten years

9 September 2017

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DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

9 September 2017

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Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

9 September 2017

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Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.

9 September 2017

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Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes

9 September 2017

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Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

9 September 2017

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Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

9 September 2017

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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

9 September 2017

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

9 September 2017

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Wnt signaling in pancreatic islets

9 September 2017

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An epigenetic signature in peripheral blood predicts active ovarian cancer

9 September 2017

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Epigenetics: a molecular link between environmental factors and type 2 diabetes

9 September 2017

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Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

9 September 2017

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9 September 2017

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Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

9 September 2017

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

9 September 2017

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The multifunctional roles of the four-and-a-half-LIM only protein FHL2.

9 September 2017

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Epigenetic differences arise during the lifetime of monozygotic twins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

9 September 2017

1 reference

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Summaries of Affymetrix GeneChip probe level data

9 September 2017

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Aging and insulin secretion

9 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

9 September 2017

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REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons

9 September 2017

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Genomic 5-methyldeoxycytidine decreases with age.

9 September 2017

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Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

9 September 2017

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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

25 September 2017

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SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations

25 September 2017

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Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes

25 September 2017

1 reference

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Effect of Aging on the Peripheral Blood Lymphocyte Count

17 June 2018

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Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

17 June 2018

1 reference

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LASAGNA-Search 2.0: integrated transcription factor binding site search and visualization in a browser

22 August 2018

1 reference

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Association of KCNQ1 and KLF14 polymorphisms and risk of type 2 diabetes mellitus: A global meta-analysis

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

High density DNA methylation array with single CpG site resolution

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

Inferring relative numbers of human leucocyte genome replications

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes

22 August 2018

1 reference

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Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS11089

Methylation of ELOVL2 gene as a new epigenetic marker of age

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821875

DNA methylation decreases in aging but not in immortal cells

2 December 2018

1 reference

12 December 2020

Pathogen inactivation of human serum facilitates its clinical use for islet cell culture and subsequent transplantation

1 reference

12 December 2020

Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector

1 reference

12 December 2020

Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS11089

1 reference

Dimensions Publication ID

7 September 2017

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7 September 2017

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