Hereditary breast and ovarian cancer: new genes in confined pathways (Q38925408)

7 September 2017

1 reference

title

Hereditary breast and ovarian cancer: new genes in confined pathways (English)

1 reference

7 September 2017

1 reference

1

Finn Cilius Nielsen

0 references

author name string

Thomas van Overeem Hansen

series ordinal

2

1 reference

7 September 2017

Claus Storgaard Sørensen

series ordinal

3

1 reference

7 September 2017

language of work or name

English

0 references

publication date

12 August 2016

1 reference

7 September 2017

published in

Nature Reviews Cancer

1 reference

7 September 2017

volume

16

1 reference

7 September 2017

issue

9

1 reference

7 September 2017

page(s)

599-612

1 reference

Mutation and cancer: statistical study of retinoblastoma

7 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Identification of the breast cancer susceptibility gene BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Meta-analysis of BRCA1 and BRCA2 penetrance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast cancer risk among male BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Hereditary breast cancer: new genetic developments, new therapeutic avenues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline RECQL mutations are associated with breast cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Gene-panel sequencing and the prediction of breast-cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

R loops: new modulators of genome dynamics and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mechanisms of ATM Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The MRE11 complex: starting from the ends.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Purified human BRCA2 stimulates RAD51-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Deciphering the BRCA1 Tumor Suppressor Network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 and BRCA2: different roles in a common pathway of genome protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rare variants in the ATM gene and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A mechanism for the suppression of homologous recombination in G1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A recurrent mutation in PALB2 in Finnish cancer families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline mutation in the RAD51B gene confers predisposition to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline mutations in RAD51D confer susceptibility to ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Genetic testing for RAD51C mutations: in the clinic and community

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast cancer in a RAD51D mutation carrier: case report and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rare mutations in XRCC2 increase the risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Rare variants in XRCC2 as breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mutations in BRIP1 confer high risk of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Replication fork stability confers chemoresistance in BRCA-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Heterozygous mutations in PALB2 cause DNA replication and damage response defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 haploinsufficiency for replication stress suppression in primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Human RecQ helicases in DNA repair, recombination, and replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Prevalence of the BLM nonsense mutation, p.Q548X, in ovarian cancer patients from Central and Eastern Europe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mammalian mismatch repair: error-free or error-prone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Risks of less common cancers in proven mutation carriers with lynch syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mismatch repair and homeologous recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ATM: expanding roles as a chief guardian of genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Tumor suppressive functions of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Li-Fraumeni syndrome: cancer risk assessment and clinical management

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The Role of Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Update on breast cancer risk prediction and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Overview of the main outcomes in breast-cancer prevention trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Risk-benefit profiles of women using tamoxifen for chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 Circos: a visualisation resource for functional analysis of missense variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ENIGMA--evidence-based network for the interpretation of germline mutant alleles: an international initiative to evaluate risk and clinical significance associated with sequence variation in BRCA1 and BRCA2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The functional importance of disease-associated mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Loss of exon identity is a common mechanism of human inherited disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Adding In Silico Assessment of Potential Splice Aberration to the Integrated Evaluation of BRCA Gene Unclassified Variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional characterization of BRCA1 gene variants by mini-gene splicing assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional assays for analysis of variants of uncertain significance in BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A guide for functional analysis of BRCA1 variants of uncertain significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A classification model for BRCA2 DNA binding domain missense variants based on homology-directed repair activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A high-throughput functional complementation assay for classification of BRCA1 missense variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Collaborative Group on Hormonal Factors in Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A refined molecular taxonomy of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Repeated observation of breast tumor subtypes in independent gene expression data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Clinical implications of the intrinsic molecular subtypes of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Identification of molecular apocrine breast tumours by microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Whole-genome characterization of chemoresistant ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The topography of mutational processes in breast cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

CDH1 germline mutations and hereditary lobular breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline CDH1 mutations in bilateral lobular carcinoma in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Women with neurofibromatosis 1 are at a moderately increased risk of developing breast cancer and should be considered for early screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Age-specific risk of breast cancer in women with neurofibromatosis type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

PTEN: a yin-yang master regulator protein in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Inherited PTEN mutations and the prediction of phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Lifetime cancer risks in individuals with germline PTEN mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Peutz-Jeghers syndrome: a systematic review and recommendations for management

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Relative frequency and morphology of cancers in STK11 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

LKB1 preserves genome integrity by stimulating BRCA1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

DNA sequencing with chain-terminating inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Gene expression patterns in ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Targeted capture and massively parallel sequencing of 12 human exomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast-cancer risk in families with mutations in PALB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline RAD51C mutations confer susceptibility to ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Relative frequency and morphology of cancers in carriers of germline TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

“BRCAness” Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated WithBRCA1andBRCA2Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

First Report of Ovarian Dysgerminoma in Cowden Syndrome with Germline PTEN Mutation and PTEN-related 10q Loss of Tumor Heterozygosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Breast cancer in young women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

NBS1 variant I171V and breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Health risks for ataxia-telangiectasia mutated heterozygotes: a systematic review, meta-analysis and evidence-based guideline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Clinical management of hereditary colorectal cancer syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Functional assays provide a robust tool for the clinical annotation of genetic variants of uncertain significance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Menopausal hormone replacement therapy and risk of ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Genome-wide transcriptome profiling of homologous recombination DNA repair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Germline 657del5 mutation in the NBS1 gene in breast cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.72

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27515922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetics of breast cancer: a topic in evolution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27515922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27515922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC.2016.72

1 reference

Dimensions Publication ID

7 September 2017

1034218927

0 references

1 reference