Role of long non-coding RNAs in the determination of β-cell identity (Q38951145)

7 September 2017

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title

Role of long non-coding RNAs in the determination of β-cell identity (English)

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7 September 2017

A Motterle

1

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7 September 2017

C Sanchez-Parra

series ordinal

2

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7 September 2017

R Regazzi

series ordinal

3

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7 September 2017

language of work or name

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1 September 2016

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Diabetes, Obesity and Metabolism

7 September 2017

published in

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7 September 2017

volume

18 Suppl 1

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7 September 2017

page(s)

41-50

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Insulin secretion in health and disease: nutrients dictate the pace

7 September 2017

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Role of non-coding RNAs in pancreatic beta-cell development and physiology

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

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Molecular mechanisms of long noncoding RNAs

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

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Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene

21 January 2018

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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

21 January 2018

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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

21 January 2018

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Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

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The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator

21 January 2018

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Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

21 January 2018

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Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor

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A strategy for probing the function of noncoding RNAs finds a repressor of NFAT

21 January 2018

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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

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lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements

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Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.

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The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

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A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA

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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

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Mechanisms of long noncoding RNA function in development and disease

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Long non-coding RNA regulation of gene expression during differentiation

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Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats.

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Emerging role of long noncoding RNAs in autoimmune diseases.

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Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases

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Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.

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The Missing lnc(RNA) between the pancreatic β-cell and diabetes

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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

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Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

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Transcriptional and epigenetic regulation in human islets

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Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.

21 January 2018

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The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.

21 January 2018

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Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution

21 January 2018

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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

21 January 2018

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Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression

21 January 2018

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GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

21 January 2018

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The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.

21 January 2018

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Pancreas organogenesis: from bud to plexus to gland

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Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.

21 January 2018

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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

21 January 2018

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Long noncoding RNAs: cellular address codes in development and disease

21 January 2018

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Multiple knockout mouse models reveal lincRNAs are required for life and brain development

21 January 2018

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βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function

21 January 2018

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Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells.

21 January 2018

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Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

21 January 2018

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Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

21 January 2018

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The long non-coding RNA Paupar regulates the expression of both local and distal genes

21 January 2018

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Implication of epigenetics in pancreas development and disease

21 January 2018

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Recent progress in genetic and epigenetic research on type 2 diabetes

21 January 2018

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Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion

21 January 2018

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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

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Signaling to NF-kappaB

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LncRNAs: New Players in Apoptosis Control.

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A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis

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A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

21 January 2018

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lncRNA-mediated regulation of the interferon response

21 January 2018

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Negative regulation of the interferon response by an interferon-induced long non-coding RNA

21 January 2018

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The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA

21 January 2018

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MEG3 noncoding RNA: a tumor suppressor

21 January 2018

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Long non-coding RNAs in Huntington's disease neurodegeneration

21 January 2018

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Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma.

21 January 2018

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Transcriptomes of the major human pancreatic cell types.

21 January 2018

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The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

21 January 2018

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Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

21 January 2018

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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.

21 January 2018

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Genome-wide identification of polycomb-associated RNAs by RIP-seq

21 January 2018

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Functional interactions among microRNAs and long noncoding RNAs

21 January 2018

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LincRNA-p21 suppresses target mRNA translation

21 January 2018

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The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.

21 January 2018

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MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.

21 January 2018

1 reference

Emerging Roles for Natural MicroRNA Sponges

21 January 2018

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The multilayered complexity of ceRNA crosstalk and competition

21 January 2018

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Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance

21 January 2018

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Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties

21 January 2018

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The imprinted H19 lncRNA antagonizes let-7 microRNAs.

21 January 2018

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From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition

21 January 2018

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Molecular biology. A circuitous route to noncoding RNA

21 January 2018

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Long noncoding RNAs: functional surprises from the RNA world

21 January 2018

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The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

21 January 2018

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Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.

21 January 2018

1 reference

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration

21 January 2018

1 reference

Databases for lncRNAs: a comparative evaluation of emerging tools

21 January 2018

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lncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs

21 January 2018

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LncReg: a reference resource for lncRNA-associated regulatory networks

21 January 2018

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Rise of the RNA machines: exploring the structure of long non-coding RNAs

21 January 2018

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Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

21 January 2018

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Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

21 January 2018

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Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

21 January 2018

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy

21 January 2018

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Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DOM.12714

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7 September 2017

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