Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease. (Q38957994)

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16 February 2020

title

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease (English)

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Giulia Cisbani

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Sébastien S. Hébert

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Emmanuel Planel

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Francesca Cicchetti

object named as

Francesca Cicchetti

14

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author name string

Anastasia Noël

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Carl Julien

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Philippe Milot-Rousseau

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Françoise Morin

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Maya Dickler

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Claudia Goupil

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François Bezeau

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Isabelle Poitras

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Stéphanie Bissonnette

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Robert A Whittington

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J Alex Parker

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Pershia Samadi

16

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publication date

8 September 2014

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16 February 2020

published in

Human Molecular Genetics

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16 February 2020

volume

24

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page(s)

86-99

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issue

1

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

16 February 2020

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.

21 January 2018

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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

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The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

21 January 2018

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Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice

21 January 2018

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Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of L-NAME on symptom progression

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Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin

21 January 2018

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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

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The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells.

21 January 2018

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The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells

21 January 2018

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MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

21 January 2018

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Mutant huntingtin alters Tau phosphorylation and subcellular distribution

21 January 2018

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The distribution of tau in the mammalian central nervous system

21 January 2018

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Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins.

21 January 2018

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Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders

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21 January 2018

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21 January 2018

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Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

21 January 2018

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21 January 2018

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21 January 2018

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Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

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An immunohistochemical investigation of the human neostriatum in Huntington's disease

21 January 2018

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Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

21 January 2018

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Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation

21 January 2018

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Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

21 January 2018

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21 January 2018

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Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals.

21 January 2018

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

21 January 2018

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

21 January 2018

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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

21 January 2018

1 reference

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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

21 January 2018

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Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.

21 January 2018

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Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies

21 January 2018

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

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Detergent-insoluble cortical Lewy body fibrils share epitopes with neurofilament and tau

21 January 2018

1 reference

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Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

21 January 2018

1 reference

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

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Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU456

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU456

Mutant huntingtin is present in neuronal grafts in Huntington disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU456

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU456

21 January 2018

Identifiers

DOI

10.1093/HMG/DDU456

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25205109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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