Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways (Q38969138)

8 September 2017

Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways (English)

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8 September 2017

X Cai-McRae

1

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8 September 2017

H Zhong

series ordinal

2

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8 September 2017

V Karantza

series ordinal

3

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8 September 2017

language of work or name

English

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publication date

4 August 2014

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8 September 2017

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8 September 2017

34

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8 September 2017

23

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8 September 2017

2968-2977

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https://scigraph.springernature.com/pub.10.1038/onc.2014.244

8 September 2017

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cites work

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HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry.

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ErbB receptors and signaling pathways in cancer

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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Reduced expression of PTEN correlates with breast cancer progression

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β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression.

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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

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The complex world of WNT receptor signalling

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p62/SQSTM1/A170: physiology and pathology

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The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease

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p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells

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The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

21 January 2018

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Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

21 January 2018

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Autophagy suppresses tumorigenesis through elimination of p62

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ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss

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Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

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p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

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The double-edged sword of autophagy modulation in cancer

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

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Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro

21 January 2018

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p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

21 January 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

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Subtle variations in Pten dose determine cancer susceptibility

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

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Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

21 January 2018

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Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2014.244

p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation.

21 January 2018

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Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein

21 January 2018

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Akt stimulates aerobic glycolysis in cancer cells

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Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling

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Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

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A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

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Induction of autophagy by amino-acid deprivation in perfused rat liver

21 January 2018

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

21 January 2018

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The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25088198

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2014.244

1 reference

Dimensions Publication ID

8 September 2017

0 references

1 reference