LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT. (Q38994951)

8 September 2017

LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT. (English)

1 reference

8 September 2017

Jacob M Kaufman

1

1 reference

8 September 2017

Joseph M Amann

2

1 reference

8 September 2017

Kyungho Park

3

1 reference

8 September 2017

Rajeswara Rao Arasada

4

1 reference

8 September 2017

Haotian Li

5

1 reference

8 September 2017

Yu Shyr

6

1 reference

8 September 2017

David P Carbone

7

1 reference

8 September 2017

language of work or name

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1 June 2014

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Journal of Thoracic Oncology

8 September 2017

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8 September 2017

9

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8 September 2017

6

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8 September 2017

794-804

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describes a project that uses

8 September 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4026179

based on heuristic

inferred from PubMed Central ID database lookup

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LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

9 September 2017

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9 September 2017

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The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss

9 September 2017

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NMD: a multifaceted response to premature translational termination

9 September 2017

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The transcriptional landscape and mutational profile of lung adenocarcinoma.

9 September 2017

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Comprehensive genomic characterization of squamous cell lung cancers

9 September 2017

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

9 September 2017

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Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.

9 September 2017

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Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation

9 September 2017

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mTOR signaling in growth control and disease

9 September 2017

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

9 September 2017

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Systematic identification of genomic markers of drug sensitivity in cancer cells

9 September 2017

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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

9 September 2017

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

9 September 2017

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

9 September 2017

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9 September 2017

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Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

9 September 2017

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FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

9 September 2017

1 reference

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Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

9 September 2017

1 reference

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Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

9 September 2017

1 reference

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

9 September 2017

1 reference

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An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

9 September 2017

1 reference

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Somatic mutations affect key pathways in lung adenocarcinoma

9 September 2017

1 reference

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LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins

9 September 2017

1 reference

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Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

LKB1 modulates lung cancer differentiation and metastasis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Prevalence and specificity of LKB1 genetic alterations in lung cancers

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

LKB1-dependent signaling pathways

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Ras, PI(3)K and mTOR signalling controls tumour cell growth

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

The LKB1 tumor suppressor negatively regulates mTOR signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4026179

10.1097/JTO.0000000000000173

2 December 2018

Identifiers

DOI

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8 September 2017

1 reference

8 September 2017

1 reference