Direct targeting of Rab-GTPase-effector interactions (Q39028691)

8 September 2017

Direct targeting of Rab-GTPase-effector interactions (English)

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8 September 2017

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8 September 2017

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8 September 2017

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8 September 2017

Philipp M Cromm

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Jochen Spiegel

object named as

Jochen Spiegel

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1

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Aymelt Itzen

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Aymelt Itzen

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3

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language of work or name

English

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publication date

31 January 2014

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Angewandte Chemie International Edition

8 September 2017

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volume

53

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8 September 2017

9

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8 September 2017

2498-2503

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The GTPase superfamily: a conserved switch for diverse cell functions

8 September 2017

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Regulation of small GTPases by GEFs, GAPs, and GDIs

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

GTPases involved in vesicular trafficking: structures and mechanisms

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Role of Rab GTPases in membrane traffic and cell physiology

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Structure-guided development of selective RabGGTase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Targeting protein prenylation for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Development of selective, potent RabGGTase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Rab GTPases implicated in inherited and acquired disorders

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Sulindac sulfide inhibits Ras signaling

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Identification and characterization of a peptidic ligand for Ras.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Interaction of a novel GDP exchange inhibitor with the Ras protein

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

An orthosteric inhibitor of the Ras-Sos interaction

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

New modalities in conformationally constrained peptides for potency, selectivity and cell permeation

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

BAX activation is initiated at a novel interaction site

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201308568

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

Inhibition of oncogenic Wnt signaling through direct targeting of -catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

21 January 2018

The Protein Data Bank

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https://api.crossref.org/works/10.1002%2FANIE.201308568

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308568

21 January 2018

Identifiers

DOI

10.1002/ANIE.201308568

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8 September 2017

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PubMed ID

24481744