Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein (Q39188679)

9 September 2017

Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein (English)

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9 September 2017

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Lisa C Crowley

3

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Mary R Cahill

object named as

Mary R Cahill

5

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Sharon L McKenna

object named as

Sharon L McKenna

6

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author name string

Baukje M Elzinga

1

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PubMed ID

23440701

9 September 2017

Michelle J Nyhan

2

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PubMed ID

23440701

9 September 2017

Tracey R O'Donovan

4

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9 September 2017

2 April 2013

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American Journal of Hematology

9 September 2017

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9 September 2017

88

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9 September 2017

6

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9 September 2017

455-462

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Monitoring treatment of chronic myeloid leukemia

9 September 2017

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A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

21 January 2018

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A coiled-coil tetramerization domain of BCR-ABL is essential for the interactions of SH2-containing signal transduction molecules

21 January 2018

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Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

21 January 2018

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Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia

21 January 2018

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Bag1 directly routes immature BCR-ABL for proteasomal degradation

21 January 2018

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Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin

21 January 2018

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

21 January 2018

1 reference

Autophagy: process and function

21 January 2018

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Autophagosome formation: core machinery and adaptations

21 January 2018

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Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

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Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

21 January 2018

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Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein

21 January 2018

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Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

21 January 2018

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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

21 January 2018

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Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment

21 January 2018

1 reference

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 January 2018

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Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity--formation of crinosomes

21 January 2018

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Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages

21 January 2018

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Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells.

21 January 2018

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Heat shock protein 90-antagonist destabilizes Bcr-Abl/HSP90 chaperone complex

21 January 2018

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Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells

21 January 2018

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Induction of autophagy during extracellular matrix detachment promotes cell survival

21 January 2018

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

21 January 2018

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Cytoprotective effect of imatinib mesylate in non-BCR-ABL-expressing cells along with autophagosome formation

21 January 2018

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The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

21 January 2018

1 reference

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

21 January 2018

1 reference

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

Autophagy: links with the proteasome

21 January 2018

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Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/AJH.23428

1 reference

9 September 2017

1 reference

PubMed ID

23440701