Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions (Q39212927)

10 September 2017

title

Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions (English)

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protein-protein interaction

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main subject

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5

Zeger Debyser

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Frauke Christ

3

object named as

Frauke Christ

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10 September 2017

Tino Wilson Sanchez

1

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Bikash Debnath

2

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Hiroyuki Otake

4

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Nouri Neamati

6

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10 September 2017

language of work or name

English

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publication date

20 December 2012

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Bioorganic & Medicinal Chemistry

10 September 2017

published in

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volume

21

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issue

4

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page(s)

957-963

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describes a project that uses

10 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6188659/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors

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12 December 2020

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

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12 December 2020

High rate of mismatch extension during reverse transcription in a single round of retrovirus replication

1 reference

12 December 2020

Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

1 reference

12 December 2020

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

1 reference

12 December 2020

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

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12 December 2020

Development and validation of a genetic algorithm for flexible docking

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12 December 2020

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

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12 December 2020

Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types

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12 December 2020

Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

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12 December 2020

Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein

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12 December 2020

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

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12 December 2020

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12 December 2020

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

1 reference

12 December 2020

Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model

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12 December 2020

Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection

1 reference

12 December 2020

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain

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12 December 2020

Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis

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12 December 2020

Isoniazid: metabolic aspects and toxicological correlates

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12 December 2020

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups

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12 December 2020

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

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12 December 2020

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

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12 December 2020

LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis

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12 December 2020

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

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12 December 2020

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

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12 December 2020

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

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12 December 2020

Evolutionary dynamics of complex networks of HIV drug-resistant strains: the case of San Francisco

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12 December 2020

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

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12 December 2020

Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug.

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12 December 2020

Identification of the LEDGF/p75 binding site in HIV-1 integrase

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12 December 2020

A role for LEDGF/p75 in targeting HIV DNA integration

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12 December 2020

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication

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12 December 2020

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

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12 December 2020

An essential role for LEDGF/p75 in HIV integration

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12 December 2020

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

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12 December 2020

Retroviral intasome assembly and inhibition of DNA strand transfer

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12 December 2020

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

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12 December 2020

10.1016/J.BMC.2012.12.012

Identifiers

DOI

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10 September 2017

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