Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors. (Q39331677)

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English	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	scientific article

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Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors (English)

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Václav Veverka

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Gill Holdsworth

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Patrick Slocombe

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Carl Doyle

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Bernadette Sweeney

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Kelly Le Riche

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Richard J Franklin

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Joanne Compson

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Daniel Brookings

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James Turner

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Jeffery Kennedy

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Rachael Garlish

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Laura Newnham

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David McMillan

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Mariusz Muzylak

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Mark D Carr

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Alistair J Henry

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Thomas Ceska

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Martyn K Robinson

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13 June 2012

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Journal of Biological Chemistry

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26464-26477

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5 February 2020

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

1 reference

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11 September 2017

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

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11 September 2017

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

1 reference

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11 September 2017

The structure of MESD45-184 brings light into the mechanism of LDLR family folding

1 reference

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11 September 2017

Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains

1 reference

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11 September 2017

Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6

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11 September 2017

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

1 reference

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11 September 2017

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

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11 September 2017

Sclerostin: a gem from the genome leads to bone-building antibodies

1 reference

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11 September 2017

Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity

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11 September 2017

Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells

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11 September 2017

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

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11 September 2017

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

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11 September 2017

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

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11 September 2017

Wnt/beta-catenin signaling: components, mechanisms, and diseases

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11 September 2017

Proximal events in Wnt signal transduction

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11 September 2017

Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

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11 September 2017

NMR structure of the Wnt modulator protein Sclerostin

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11 September 2017

Wnt signaling in development, disease and translational medicine.

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11 September 2017

Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

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11 September 2017

Wnt/beta-catenin signaling: new (and old) players and new insights

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11 September 2017

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

1 reference

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11 September 2017

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

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11 September 2017

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

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11 September 2017

Parameters of LRP5 from a structural and molecular perspective

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11 September 2017

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

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11 September 2017

Functional genomic analysis of the Wnt-wingless signaling pathway

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11 September 2017

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

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11 September 2017

The Wnt signaling pathway in development and disease

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LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way

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11 September 2017

A mechanism for Wnt coreceptor activation

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11 September 2017

Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface

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11 September 2017

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

1 reference

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Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

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11 September 2017

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

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11 September 2017

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

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11 September 2017

Inhibition of Wnt activity induces heart formation from posterior mesoderm

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11 September 2017

An LDL-receptor-related protein mediates Wnt signalling in mice

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11 September 2017

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11 September 2017

DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3.

1 reference

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14 September 2017

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

1 reference

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14 September 2017

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

1 reference

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15 June 2018

Sclerostin binds and regulates the activity of cysteine-rich protein 61.

1 reference

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15 June 2018

WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.

1 reference

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21 August 2018

The natural history of sclerosteosis

1 reference

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21 August 2018

Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.

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21 August 2018

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10.1074/JBC.M112.350108

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5 February 2020

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5 February 2020

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5 February 2020

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