Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. (Q39348126)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586610%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay (English)

1 reference

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1 February 2020

main subject

protein ubiquitination

1 reference

4

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1 February 2020

Rachid Skouta

5

1 reference

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1 February 2020

6

Carol Prives

1 reference

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1 February 2020

author name string

Ariel G Herman

1

1 reference

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1 February 2020

Miki Hayano

2

1 reference

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1 February 2020

Masha V Poyurovsky

3

1 reference

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1 February 2020

Brent R Stockwell

7

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publication date

28 July 2011

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1 February 2020

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1 February 2020

volume

1

1 reference

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issue

4

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page(s)

312-325

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describes a project that uses

1 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3353153/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

1 reference

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Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

11 September 2017

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The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function

11 September 2017

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Identification and characterization of the first small molecule inhibitor of MDMX

11 September 2017

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Blinded by the Light: The Growing Complexity of p53

11 September 2017

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Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

11 September 2017

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

11 September 2017

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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

11 September 2017

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

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Tumor suppression and normal aging in mice with constitutively high p53 activity

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

11 September 2017

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

11 September 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

MDM2 promotes ubiquitination and degradation of MDMX

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Decision making by p53: life, death and cancer

11 September 2017

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

11 September 2017

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

11 September 2017

1 reference

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

11 September 2017

1 reference

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Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins

11 September 2017

1 reference

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

11 September 2017

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

11 September 2017

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

11 September 2017

1 reference

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

11 September 2017

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

11 September 2017

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MDM2 interacts with MDMX through their RING finger domains

11 September 2017

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

11 September 2017

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11 September 2017

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11 September 2017

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p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

11 September 2017

1 reference

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Regulation of p53 stability by Mdm2

11 September 2017

1 reference

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Mdm2 promotes the rapid degradation of p53

11 September 2017

1 reference

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MDMX: a novel p53-binding protein with some functional properties of MDM2

11 September 2017

1 reference

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The p53-mdm-2 autoregulatory feedback loop

11 September 2017

1 reference

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

11 September 2017

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

11 September 2017

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

DNA damage-induced MDMX degradation is mediated by MDM2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

Tumor promotion by Mdm2 splice variants unable to bind p53.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353153

mdmx is a negative regulator of p53 activity in vivo

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22586610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-11-0104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586610%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586610%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22586610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22586610%20AND%20SRC:MED&resulttype=core&format=json