Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors. (Q39384360)

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25 January 2020

title

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors (English)

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3

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Alex MacKerell

8

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author name string

Jeremy L Yap

1

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Xiaobo Cao

2

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Kwan-Young Jung

4

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Chander Peddaboina

5

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Paul T Wilder

6

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Anjan Nan

7

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W Roy Smythe

9

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Steven Fletcher

10

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publication date

7 March 2012

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Organic and Biomolecular Chemistry

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published in

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volume

10

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issue

15

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page(s)

2928-2933

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Helix-mediated protein--protein interactions as targets for intervention using foldamers

25 January 2020

cites work

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Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

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Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

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Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

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Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex

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Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

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Synthesis of pyridazine-based scaffolds as alpha-helix mimetics

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Cell death: critical control points

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Bcl2/bcl-xL inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma

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MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer

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Controlling curvature in a family of oligoamide alpha-helix mimetics.

21 January 2018

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Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

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Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C2OB07125H

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25 January 2020

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