Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery (Q39442534)

12 September 2017

Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery (English)

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12 September 2017

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Jörg B Schulz

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12 September 2017

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Sebastian Kügler

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12 September 2017

Anja Drinkut

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12 September 2017

Yuliya Tereshchenko

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2

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12 September 2017

Mathias Bähr

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4

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12 September 2017

15 November 2011

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20

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3

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534-543

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describes a project that uses

12 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3293619/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

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Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson's disease

12 September 2017

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Molecular evolution of adeno-associated virus for enhanced glial gene delivery

12 September 2017

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Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys

12 September 2017

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12 September 2017

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Scientific rationale for the development of gene therapy strategies for Parkinson's disease

12 September 2017

1 reference

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Driving GDNF expression: the green and the red traffic lights

12 September 2017

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12 September 2017

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Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor

12 September 2017

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12 September 2017

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RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.

12 September 2017

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12 September 2017

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Functional recovery in parkinsonian monkeys treated with GDNF

12 September 2017

1 reference

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Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.

12 September 2017

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Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

12 September 2017

1 reference

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Anterograde axonal transport of AAV2-GDNF in rat basal ganglia

12 September 2017

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Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.

14 September 2017

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Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

14 September 2017

1 reference

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Absolute requirement of GDNF for adult catecholaminergic neuron survival

14 September 2017

1 reference

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Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats.

14 September 2017

1 reference

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

14 September 2017

1 reference

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Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity

14 September 2017

1 reference

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Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

14 September 2017

1 reference

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Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease.

14 September 2017

1 reference

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Delivery of GDNF by an E1,E3/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease

14 September 2017

1 reference

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Glial cell line neurotrophic factor-family receptor alpha-1 is present in central neurons with distinct phenotypes

14 September 2017

1 reference

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

14 September 2017

1 reference

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Anterograde axonal transport of internalized GDNF in sensory and motor neurons

14 September 2017

1 reference

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Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

25 September 2017

1 reference

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Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains

25 September 2017

1 reference

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Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

25 September 2017

1 reference

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Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRalpha1 as well as GDNF in vivo

25 September 2017

1 reference

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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

25 September 2017

1 reference

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The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages

25 September 2017

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Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Nigral inhibition of GABAergic neurons in mouse superior colliculus.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

The visual-oculomotor striatum of the cat: functional relationship to the superior colliculus

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Nigrotectal projections in the primate Galago crassicaudatus

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

The crossed nigrostriatal projection decussates in the ventral tegmental decussation

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Gene expression profiles of reactive astrocytes in dopamine-depleted striatum

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

21 August 2018

1 reference

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Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors

21 August 2018

1 reference

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Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293619

GFAP promoter elements required for region-specific and astrocyte-specific expression

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22086235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MT.2011.249

1 reference

12 September 2017

1 reference

12 September 2017

PubMed publication ID

22086235

1 reference