Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB. (Q39511370)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900278%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB (English)

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20 March 2020

7

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20 March 2020

author name string

Mariko Nakayama

1

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20 March 2020

Shoya Yamada

2

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20 March 2020

Fuminori Ohsawa

3

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20 March 2020

Yui Ohta

4

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20 March 2020

Kohei Kawata

5

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20 March 2020

Makoto Makishima

6

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20 March 2020

publication date

27 September 2011

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ACS Medicinal Chemistry Letters

20 March 2020

published in

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20 March 2020

volume

2

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20 March 2020

page(s)

896-900

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20 March 2020

issue

12

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The “Phantom Effect” of the Rexinoid LG100754: Structural and Functional Insights

20 March 2020

cites work

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12 September 2017

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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

12 September 2017

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Design of selective nuclear receptor modulators: RAR and RXR as a case study

12 September 2017

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RAR and RXR modulation in cancer and metabolic disease

12 September 2017

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The optimal use of bexarotene in cutaneous T-cell lymphoma

12 September 2017

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Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome

12 September 2017

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International Union of Pharmacology. LXIII. Retinoid X receptors

12 September 2017

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Retinoid x receptor heterodimers in the metabolic syndrome

12 September 2017

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Some quantitative uses of drug antagonists

12 September 2017

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Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes

12 September 2017

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Retinoid X receptor-antagonistic diazepinylbenzoic acids

12 September 2017

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Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

12 September 2017

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Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation

15 June 2018

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The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).

21 August 2018

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Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

21 August 2018

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Determinants of retinoid X receptor transcriptional antagonism

21 August 2018

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Structural determinants of allosteric ligand activation in RXR heterodimers.

21 August 2018

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Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions

21 August 2018

1 reference

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Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents

21 August 2018

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Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids

21 August 2018

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Sequence of intramolecular carbonylation and asymmetric hydrogenation reactions: highly regio- and enantioselective synthesis of medium ring tricyclic lactams

21 August 2018

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12 December 2020

Central hypothyroidism associated with retinoid X receptor-selective ligands

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12 December 2020

The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

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12 December 2020

Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation

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12 December 2020

Regulation of Retinoidal Actions by Diazepinylbenzoic Acids.1Retinoid Synergists Which Activate the RXR−RAR Heterodimers

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12 December 2020

Identifiers

DOI

10.1021/ML200197E

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900278%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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20 March 2020

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