Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. (Q39564257)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22919070%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs (English)

1 reference

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11 February 2020

0 references

1 reference

interspecific variation

1 reference

1

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11 February 2020

Elisabeth Rexen Ulven

2

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11 February 2020

Trond Ulven

7

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11 February 2020

8

Graeme Milligan

1 reference

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11 February 2020

author name string

Irina G Tikhonova

3

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11 February 2020

Manuel Grundmann

4

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11 February 2020

Evi Kostenis

5

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11 February 2020

David R Adams

6

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11 February 2020

language of work or name

English

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publication date

23 August 2012

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11 February 2020

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11 February 2020

volume

26

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11 February 2020

issue

12

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11 February 2020

page(s)

4951-4965

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Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

11 February 2020

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Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

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Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

14 September 2017

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Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation

14 September 2017

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GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance

14 September 2017

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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

14 September 2017

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A chemical-genetic approach to study G protein regulation of beta cell function in vivo.

14 September 2017

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Lipid receptors and islet function: therapeutic implications?

14 September 2017

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Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.

14 September 2017

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The structure and function of G-protein-coupled receptors

14 September 2017

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The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

14 September 2017

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Discovery of new GPCR biology: one receptor structure at a time

14 September 2017

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International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions

14 September 2017

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Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

14 September 2017

1 reference

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Fatty acid binding receptors and their physiological role in type 2 diabetes

14 September 2017

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Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

14 September 2017

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Engineering GPCR signaling pathways with RASSLs

14 September 2017

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Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening

14 September 2017

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Functional selectivity through protean and biased agonism: who steers the ship?

14 September 2017

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Identification of residues important for agonist recognition and activation in GPR40

14 September 2017

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Beta-arrestin-biased ligands at seven-transmembrane receptors

14 September 2017

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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

14 September 2017

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

14 September 2017

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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

14 September 2017

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14 September 2017

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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

14 September 2017

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14 September 2017

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Food applications of sorbic acid and its salts

14 September 2017

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Toxicology of sorbic acid and sorbates

14 September 2017

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Energy contributions of volatile fatty acids from the gastrointestinal tract in various species

14 September 2017

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Constitutive activity of GPR40/FFA1 intrinsic or assay dependent?

14 September 2017

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Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids

17 June 2018

1 reference

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Short communication: Presence of G protein-coupled receptor 43 in rumen epithelium but not in the islets of Langerhans in cattle

17 June 2018

1 reference

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Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

21 August 2018

1 reference

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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

21 August 2018

1 reference

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Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

21 August 2018

1 reference

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G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation

21 August 2018

1 reference

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Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes

21 August 2018

1 reference

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Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.

21 August 2018

1 reference

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A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

21 August 2018

1 reference

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21 August 2018

Identifiers

DOI

10.1096/FJ.12-213314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22919070%20AND%20SRC:MED&resulttype=core&format=json

release_k4xlvv3m2rdv7esmpyhc4jescq

11 February 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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11 February 2020

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