Inhibition of GSK3 promotes replication and survival of pancreatic beta cells (Q40180167)

18 September 2017

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells (English)

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18 September 2017

Rainer Mussmann

1

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18 September 2017

Marcus Geese

2

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18 September 2017

Friedrich Harder

3

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18 September 2017

Simone Kegel

4

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18 September 2017

Uwe Andag

5

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18 September 2017

Alexander Lomow

6

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18 September 2017

Ulrike Burk

7

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18 September 2017

Daria Onichtchouk

8

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18 September 2017

Cord Dohrmann

9

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18 September 2017

Matthias Austen

10

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18 September 2017

language of work or name

English

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publication date

22 January 2007

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

282

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18 September 2017

16

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18 September 2017

12030-12037

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The stages of type 1A diabetes: 2005.

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Mechanisms of beta-cell death in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Endocrine pancreas plasticity under physiological and pathological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

GLP-1 based therapy for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Therapeutic approaches to preserve islet mass in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Regulation of pancreatic beta-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Regeneration of the pancreatic beta cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Growth factors and beta cell replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

cDNA cloning and properties of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

GSK-3: tricks of the trade for a multi-tasking kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Pharmacological inhibitors of glycogen synthase kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

The glamour and gloom of glycogen synthase kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Islet beta cell failure in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

GSK-3-selective inhibitors derived from Tyrian purple indirubins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Molecular targets of lithium action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Minireview: transcriptional regulation in pancreatic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Stabilization of beta-catenin impacts pancreas growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Beta-catenin is essential for pancreatic acinar but not islet development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

A novel approach to increase human islet cell mass while preserving beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609637200

21 January 2018

Identifiers

DOI

10.1074/JBC.M609637200

1 reference

release_jmf5d7y4ybfhjka4w2wdrhz72y

18 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/jmf5d7y4ybfhjka4w2wdrhz72y

mapped directly with Wikidata item

24 November 2022

based on heuristic

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