Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress. (Q39632814)

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16 January 2020

title

Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress (English)

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16 January 2020

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1

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16 January 2020

Alberto Bavelloni

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16 January 2020

Manuela Piazzi

3

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16 January 2020

Francesca Tagliavini

4

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16 January 2020

author name string

I Faenza

5

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16 January 2020

A M Martelli

6

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16 January 2020

M Y Follo

7

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16 January 2020

L Cocco

8

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16 January 2020

publication date

12 November 2010

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16 January 2020

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16 January 2020

volume

25

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16 January 2020

issue

2

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16 January 2020

page(s)

236-245

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https://scigraph.springernature.com/pub.10.1038/leu.2010.264

16 January 2020

exact match

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PKR; a sentinel kinase for cellular stress

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An antiviral response directed by PKR phosphorylation of the RNA helicase A

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New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses

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Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

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Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

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PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation

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PKR is activated in MDS patients and its subcellular localization depends on disease severity

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Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR

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Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

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The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation

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Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.

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7 January 2021

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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7 January 2021

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

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7 January 2021

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7 January 2021

RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection

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7 January 2021

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

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7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

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7 January 2021

Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.

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7 January 2021

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An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

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7 January 2021

The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).

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7 January 2021

The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation

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7 January 2021

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7 January 2021

Antiviral action of the tumor suppressor ARF

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Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

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7 January 2021