Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway (Q39759975)

14 September 2017

Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway (English)

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14 September 2017

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Zineb Mounir

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14 September 2017

Jothi Latha Krishnamoorthy

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14 September 2017

Gavin P Robertson

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Donalyn Scheuner

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Randal J Kaufman

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Maria-Magdalena Georgescu

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Antonis E Koromilas

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22 December 2009

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ra85

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describes a project that uses

14 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3684442/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

1 reference

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Targeting the phosphoinositide 3-kinase pathway in cancer

22 September 2017

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Molecular mechanisms of mTOR-mediated translational control

22 September 2017

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

22 September 2017

1 reference

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Post-translational regulation of PTEN.

22 September 2017

1 reference

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PTEN: a new guardian of the genome.

22 September 2017

1 reference

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Targeting the eukaryotic translation initiation factor 4E for cancer therapy

22 September 2017

1 reference

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The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

22 September 2017

1 reference

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AKT/PKB signaling: navigating downstream

22 September 2017

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A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

22 September 2017

1 reference

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PRAS40 deregulates apoptosis in malignant melanoma

22 September 2017

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Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.

22 September 2017

1 reference

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Essential role for nuclear PTEN in maintaining chromosomal integrity

22 September 2017

1 reference

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

22 September 2017

1 reference

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Coping with stress: eIF2 kinases and translational control

22 September 2017

1 reference

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Translational control in stress and apoptosis

22 September 2017

1 reference

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Phosphatase and tensin homologue growth suppression without phosphatase

22 September 2017

1 reference

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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

22 September 2017

1 reference

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Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

22 September 2017

1 reference

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Signaling control of mRNA translation in cancer pathogenesis

22 September 2017

1 reference

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Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

22 September 2017

1 reference

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The protein kinase PKR: a molecular clock that sequentially activates survival and death programs

22 September 2017

1 reference

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

22 September 2017

1 reference

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PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

22 September 2017

1 reference

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

PKR protection against intranasal vesicular stomatitis virus infection is mouse strain dependent

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3684442

Purification and catalytic properties of human caspase family members

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20029030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2000389

1 reference

14 September 2017

1 reference

14 September 2017

1 reference