Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes (Q39676482)

13 September 2017

Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes (English)

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13 September 2017

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Ezio Bonifacio

6

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author name string

Peter Achenbach

1

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13 September 2017

Kerstin Koczwara

2

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13 September 2017

Annette Knopff

3

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13 September 2017

Heike Naserke

4

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13 September 2017

Anette-G Ziegler

5

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13 September 2017

language of work or name

English

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publication date

1 August 2004

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Journal of Clinical Investigation

13 September 2017

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13 September 2017

114

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13 September 2017

589-597

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13 September 2017

4

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

13 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Hypermutation in antibody affinity maturation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Structural stability in the 4-zinc human insulin hexamer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Proinsulin: a proposed three-dimensional structure

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Frequency of B cells committed to the production of antibodies to insulin in newly diagnosed patients with insulin-dependent diabetes mellitus and generation of high affinity human monoclonal IgG to insulin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Autoantibodies to insulin have similar affinity to that of antibodies to exogenous insulin but lower binding capacity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Insulin autoantibodies and insulin antibodies have similar binding characteristics.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503771

Proinsulin-specific autoantibodies are relatively infrequent in young offspring with pre-type 1 diabetes

21 August 2018

1 reference

12 December 2020

Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics

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12 December 2020

Equilibrium binding studies of insulin antibodies in diabetic subjects

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12 December 2020

Methimazole and insulin autoimmune syndrome with hypoglycemia

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12 December 2020

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

1 reference

12 December 2020

Insulin autoantibody polymorphisms with greater discrimination for diabetes in humans

1 reference

12 December 2020

Characterization of insulin autoantibodies in relatives of patients with type I diabetes

1 reference

12 December 2020

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study

1 reference

12 December 2020

Immunoglobulin G insulin autoantibodies in BABYDIAB offspring appear postnatally: sensitive early detection using a protein A/G-based radiobinding assay

1 reference

12 December 2020

T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes

1 reference

12 December 2020

Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation

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12 December 2020

The new approach to immunology

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12 December 2020

Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody

1 reference

12 December 2020

Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population

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12 December 2020

Identifiers

DOI

10.1172/JCI200421307

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13 September 2017

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13 September 2017

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