Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. (Q39718673)

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30 January 2020

title

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3 (English)

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30 January 2020

6

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30 January 2020

author name string

E Law

1

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30 January 2020

S Lu

2

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30 January 2020

T J Kieffer

3

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30 January 2020

G L Warnock

4

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30 January 2020

Z Ao

5

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30 January 2020

L Marzban

7

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publication date

6 April 2010

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30 January 2020

number of pages

13

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inferred from page(s)

published in

Diabetologia

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30 January 2020

volume

53

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30 January 2020

issue

7

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30 January 2020

page(s)

1415-1427

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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

30 January 2020

cites work

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Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

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Widespread amyloid deposition in transplanted human pancreatic islets

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

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Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

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Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

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Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture

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Rapid deposition of amyloid in human islets transplanted into nude mice.

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Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance

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Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases

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Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

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Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

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Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

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Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death

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Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

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Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

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Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

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Glucose- and time-dependence of islet amyloid formation in vitro

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Type 2 diabetes, insulin secretion and beta-cell mass

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Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

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12 December 2020

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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12 December 2020

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress

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12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

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12 December 2020

Apoptotic pathways: ten minutes to dead

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12 December 2020

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

Amyloid ion channels: a common structural link for protein-misfolding disease

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12 December 2020

Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

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12 December 2020

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

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12 December 2020

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.

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12 December 2020

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

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12 December 2020

Islet amyloid polypeptide and type 2 diabetes

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12 December 2020

Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus

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12 December 2020

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

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12 December 2020

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

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12 December 2020

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

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12 December 2020

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

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12 December 2020

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

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12 December 2020

Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation

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12 December 2020

The cellular response to protein misfolding in the endoplasmic reticulum.

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12 December 2020

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

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12 December 2020

Fine structure of islets of Langerhans in insular amyloidosis

1 reference

12 December 2020