Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. (Q39856102)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19419202%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity (English)

1 reference

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Alexandra Martha Zoya Slawin

27 January 2020

author

6

1 reference

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27 January 2020

Nicholas J Westwood

9

1 reference

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27 January 2020

author name string

Federico Medda

1

1 reference

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27 January 2020

Rupert J M Russell

2

1 reference

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27 January 2020

Maureen Higgins

3

1 reference

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27 January 2020

Anna R McCarthy

4

1 reference

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27 January 2020

Johanna Campbell

5

1 reference

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27 January 2020

David P Lane

7

1 reference

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27 January 2020

Sonia Lain

8

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27 January 2020

language of work or name

English

0 references

publication date

1 May 2009

1 reference

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Journal of Medicinal Chemistry

27 January 2020

published in

1 reference

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27 January 2020

volume

52

1 reference

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27 January 2020

issue

9

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27 January 2020

page(s)

2673-2682

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Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

27 January 2020

cites work

1 reference

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Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

22 September 2017

1 reference

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

22 September 2017

1 reference

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p53 in health and disease

22 September 2017

1 reference

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

22 September 2017

1 reference

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Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

22 September 2017

1 reference

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Pilot screening programme for small molecule activators of p53.

22 September 2017

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

22 September 2017

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

22 September 2017

1 reference

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Structure and autoregulation of the yeast Hst2 homolog of Sir2

22 September 2017

1 reference

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

22 September 2017

1 reference

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

22 September 2017

1 reference

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PHENIX: building new software for automated crystallographic structure determination

22 September 2017

1 reference

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

22 September 2017

1 reference

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Identification of a small molecule inhibitor of Sir2p

22 September 2017

1 reference

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

22 September 2017

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

22 September 2017

1 reference

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Structure of the histone deacetylase SIRT2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691587

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2691587

Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation

22 September 2017

1 reference

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Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

17 June 2018

1 reference

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Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

20 August 2018

1 reference

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Structural basis for the mechanism and regulation of Sir2 enzymes.

20 August 2018

1 reference

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Comparative and pharmacophore model for deacetylase SIRT1

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19419202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM8014298

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19419202%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19419202%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference