Gene silencing by synthetic U1 adaptors (Q39883594)

15 September 2017

Gene silencing by synthetic U1 adaptors (English)

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15 September 2017

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Rafal Goraczniak

1

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15 September 2017

Mark A Behlke

series ordinal

2

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15 September 2017

Samuel I Gunderson

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3

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15 September 2017

15 February 2009

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15 September 2017

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15 September 2017

27

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15 September 2017

3

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15 September 2017

257-263

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https://scigraph.springernature.com/pub.10.1038/nbt.1525

15 September 2017

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cites work

Unlocking the potential of the human genome with RNA interference

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Strategies for silencing human disease using RNA interference

21 January 2018

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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Reduction of target gene expression by a modified U1 snRNA.

21 January 2018

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Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA.

21 January 2018

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Modified U1 snRNA suppresses expression of a targeted endogenous RNA by inhibiting polyadenylation of the transcript

21 January 2018

1 reference

Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions

21 January 2018

1 reference

A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation.

21 January 2018

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U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase.

21 January 2018

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Requirements for gene silencing mediated by U1 snRNA binding to a target sequence

21 January 2018

1 reference

The regulatory element in the 3'-untranslated region of human papillomavirus 16 inhibits expression by binding CUG-binding protein 1

21 January 2018

1 reference

Design of antisense oligonucleotides stabilized by locked nucleic acids

21 January 2018

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Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

21 January 2018

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21 January 2018

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Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

21 January 2018

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Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells

21 January 2018

1 reference

Raf kinase as a target for anticancer therapeutics

21 January 2018

1 reference

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

21 January 2018

1 reference

Abrogation of c-Raf expression induces apoptosis in tumor cells.

21 January 2018

1 reference

Identification of sequence motifs significantly associated with antisense activity

21 January 2018

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Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor

21 January 2018

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Functional polarity is introduced by Dicer processing of short substrate RNAs

21 January 2018

1 reference

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

1 reference

Mechanisms of gene silencing by double-stranded RNA

21 January 2018

1 reference

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

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RNA interference and chemically modified small interfering RNAs

21 January 2018

1 reference

21 January 2018

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3' end mRNA processing: molecular mechanisms and implications for health and disease

21 January 2018

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A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics

21 January 2018

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Characterization of modified antisense oligonucleotides in Xenopus laevis embryos

21 January 2018

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12 December 2020

Identification of new poly(A) polymerase-inhibitory proteins capable of regulating pre-mRNA polyadenylation

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12 December 2020

Protein functions in pre-mRNA splicing

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12 December 2020

Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NBT.1525

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Dimensions Publication ID

15 September 2017

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