Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. (Q39912728)

15 September 2017

Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. (English)

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15 September 2017

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F Demarchi

4

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author name string

C Bertoli

1

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15 September 2017

T Copetti

2

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15 September 2017

E W-F Lam

3

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15 September 2017

C Schneider

5

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15 September 2017

language of work or name

English

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publication date

24 November 2008

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15 September 2017

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15 September 2017

28

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15 September 2017

5

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15 September 2017

721-733

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https://scigraph.springernature.com/pub.10.1038/onc.2008.425

15 September 2017

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Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Calpain activity is generally elevated during transformation but has oncogene-specific biological functions

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Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein

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PP2A regulates the pro-apoptotic activity of FOXO1.

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Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

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Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.425

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Dimensions Publication ID

15 September 2017

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